1-(tert-butyloxycarbonyl)methyl-4-phenyl-1H-1,2,3-triazole

Base Information

• Chemical Name: 1-(tert-butyloxycarbonyl)methyl-4-phenyl-1H-1,2,3-triazole
• CAS No.: 1233345-73-7
• Molecular Formula: C₁₄H₁₇N₃O₂
• Molecular Weight: 259.308
• Mol file: 1233345-73-7.mol

Synonyms:1-(tert-butyloxycarbonyl)methyl-4-phenyl-1H-1,2,3-triazole

Chemical Property of 1-(tert-butyloxycarbonyl)methyl-4-phenyl-1H-1,2,3-triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(tert-butyloxycarbonyl)methyl-4-phenyl-1H-1,2,3-triazole

There total 1 articles about 1-(tert-butyloxycarbonyl)methyl-4-phenyl-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

tert-butyl 2-azidoacetate (6367-36-8) + phenylacetylene (536-74-3) → 1-(tert-butyloxycarbonyl)methyl-4-phenyl-1H-1,2,3-triazole (1233345-73-7)

Guidance literature:

With sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; for 1.16667h;

DOI:10.1002/aoc.6017

Reference yield: 80.0%

bromobenzene (108-86-1,52753-63-6) + 1-(tert-butyloxycarbonyl)methyl-4-phenyl-1H-1,2,3-triazole (1233345-73-7) → tert-butyl 2-(4,5-diphenyl-1H-1,2,3-triazol-1-yl)acetate

Guidance literature:

With palladium diacetate; potassium carbonate; triphenylphosphine; In toluene; at 120 ℃; for 24h; Inert atmosphere;

DOI:10.3390/molecules21101268

Reference yield:

1-(tert-butyloxycarbonyl)methyl-4-phenyl-1H-1,2,3-triazole (1233345-73-7) → 2-(4-phenyl-1H-1,2, 3-triazol-1-yl) acetic acid (51720-20-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 35 ℃; for 3h;

DOI:10.1016/j.bmcl.2016.11.012

upstream raw materials:

tert-butyl 2-azidoacetate

phenylacetylene

Downstream raw materials:

2-(4-phenyl-1H-1,2, 3-triazol-1-yl) acetic acid