7-benzyl-8-bromo-1-ethyl-3-isobutyl-1H-purine-2,6(3H,7H)-dione

Base Information

• Chemical Name: 7-benzyl-8-bromo-1-ethyl-3-isobutyl-1H-purine-2,6(3H,7H)-dione
• CAS No.: 865452-32-0
• Molecular Formula: C₁₈H₂₁BrN₄O₂
• Molecular Weight: 405.294
• Mol file: 865452-32-0.mol

Synonyms:7-benzyl-8-bromo-1-ethyl-3-isobutyl-1H-purine-2,6(3H,7H)-dione

Chemical Property of 7-benzyl-8-bromo-1-ethyl-3-isobutyl-1H-purine-2,6(3H,7H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-benzyl-8-bromo-1-ethyl-3-isobutyl-1H-purine-2,6(3H,7H)-dione

There total 8 articles about 7-benzyl-8-bromo-1-ethyl-3-isobutyl-1H-purine-2,6(3H,7H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

7-benzyl-8-bromo-3-isobutyl-1H-purine-2,6(3H,7H)-dione + ethyl iodide (75-03-6) → 7-benzyl-8-bromo-1-ethyl-3-isobutyl-1H-purine-2,6(3H,7H)-dione (865452-32-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 12h;

DOI:10.1007/s00044-021-02722-9

Reference yield:

1-ethyl-3-isobutylxanthine (96654-24-9) → 7-benzyl-8-bromo-1-ethyl-3-isobutyl-1H-purine-2,6(3H,7H)-dione (865452-32-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Br₂; NaOAc; AcOH

2: K₂CO₃ / dimethylformamide

With bromine; sodium acetate; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00646-7

Reference yield:

7-benzyl-1-ethyl-3,7-dihydro-purine-2,6-dione → 7-benzyl-8-bromo-1-ethyl-3-isobutyl-1H-purine-2,6(3H,7H)-dione (865452-32-0)

Guidance literature:

Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylformamide

2: HCONH₄; Pd(OH)2 / methanol

3: Br₂; NaOAc; AcOH

4: K₂CO₃ / dimethylformamide

With palladium dihydroxide; bromine; sodium acetate; potassium carbonate; acetic acid; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00646-7

upstream raw materials:

benzyl bromide

8-bromo-1-ethyl-3-isobutyl-3,7-dihydro-purine-2,6-dione

1-ethyl-3-isobutylxanthine

7-benzyl-1-ethyl-3-isobutyl-3,7-dihydro-purine-2,6-dione