Technology Process of C19H26ClNO4
There total 7 articles about C19H26ClNO4 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap;
In
dichloromethane;
at 0 - 20 ℃;
for 12.75h;
DOI:10.1021/ol300342n
- Guidance literature:
-
Multi-step reaction with 3 steps
1: (R)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanoltrimethylsilyl ether / methanol; 1,2-dichloro-ethane / 240 h / -25 °C
2: sodium tetrahydroborate / methanol / 0.5 h / 0 °C
3: dmap / dichloromethane / 12.75 h / 0 - 20 °C
With
dmap; sodium tetrahydroborate; (R)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanoltrimethylsilyl ether;
In
methanol; dichloromethane; 1,2-dichloro-ethane;
1: intramolecular Michael addition;
DOI:10.1021/ol300342n
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triphenylphosphine / tetrahydrofuran; water / 15 h
1.2: 12 h
2.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 5 h / 20 °C
3.1: (R)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanoltrimethylsilyl ether / methanol; 1,2-dichloro-ethane / 240 h / -25 °C
4.1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C
5.1: dmap / dichloromethane / 12.75 h / 0 - 20 °C
With
dmap; sodium tetrahydroborate; Hoveyda-Grubbs catalyst second generation; (R)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanoltrimethylsilyl ether; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane;
3.1: intramolecular Michael addition;
DOI:10.1021/ol300342n
