6-[N-(4-bromo-3-chlorophenyl)methanesulfonamido]-2-(4-chlorophenyl)-5-cyclopropyl-1-benzofuran-3-carboxylic acid

Base Information

Chemical Name:6-[N-(4-bromo-3-chlorophenyl)methanesulfonamido]-2-(4-chlorophenyl)-5-cyclopropyl-1-benzofuran-3-carboxylic acid
CAS No.:1423007-79-7
Molecular Formula:C₂₅H₁₈BrCl₂NO₅S
Molecular Weight:595.298
Hs Code.:

Synonyms:6-[N-(4-bromo-3-chlorophenyl)methanesulfonamido]-2-(4-chlorophenyl)-5-cyclopropyl-1-benzofuran-3-carboxylic acid

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Chemical Property of 6-[N-(4-bromo-3-chlorophenyl)methanesulfonamido]-2-(4-chlorophenyl)-5-cyclopropyl-1-benzofuran-3-carboxylic acid

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Technology Process of 6-[N-(4-bromo-3-chlorophenyl)methanesulfonamido]-2-(4-chlorophenyl)-5-cyclopropyl-1-benzofuran-3-carboxylic acid

There total 13 articles about 6-[N-(4-bromo-3-chlorophenyl)methanesulfonamido]-2-(4-chlorophenyl)-5-cyclopropyl-1-benzofuran-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1423007-78-6
ethyl 6-[N-(4-bromo-3-chlorophenyl)methanesulfonamido]-2-(4-chlorophenyl)-5-cyclopropyl-1-benzofuran-3-carboxylate

: 1423007-79-7
6-[N-(4-bromo-3-chlorophenyl)methanesulfonamido]-2-(4-chlorophenyl)-5-cyclopropyl-1-benzofuran-3-carboxylic acid

Guidance literature:: With methanol; sodium hydroxide; In tetrahydrofuran; at 20 - 60 ℃; for 5h;

Reference yield:

: 1331943-20-4
ethyl 2-(4-chlorophenyl)-5-cyclopropyl-6-nitrobenzofuran-3-carboxylate

: 1423007-79-7
6-[N-(4-bromo-3-chlorophenyl)methanesulfonamido]-2-(4-chlorophenyl)-5-cyclopropyl-1-benzofuran-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium 10% on activated carbon; hydrogenchloride; hydrogen / water; ethyl acetate / 8 h / 20 °C / 3000.3 Torr

2.1: copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 °C

3.2: -78 - 20 °C

4.1: sodium hydroxide; methanol / tetrahydrofuran / 5 h / 20 - 60 °C

With hydrogenchloride; methanol; palladium 10% on activated carbon; hydrogen; copper diacetate; triethylamine; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; ethyl acetate;

Reference yield:

: 1331943-21-5
ethyl 6-amino-2-(4-chlorophenyl)-5-cyclopropylbenzofuran-3-carboxylate

: 1423007-79-7
6-[N-(4-bromo-3-chlorophenyl)methanesulfonamido]-2-(4-chlorophenyl)-5-cyclopropyl-1-benzofuran-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 °C

2.2: -78 - 20 °C

3.1: sodium hydroxide; methanol / tetrahydrofuran / 5 h / 20 - 60 °C

With methanol; copper diacetate; triethylamine; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;