6-amino-1-benzyl-5-methyl(phenyl)carboxamido-2,3-dioxo-1,2,3,4-tetrahydropyrimidine

Base Information

Chemical Name:6-amino-1-benzyl-5-methyl(phenyl)carboxamido-2,3-dioxo-1,2,3,4-tetrahydropyrimidine
CAS No.:1026890-84-5
Molecular Formula:C₁₉H₁₈N₄O₃
Molecular Weight:350.377
Hs Code.:

Synonyms:6-amino-1-benzyl-5-methyl(phenyl)carboxamido-2,3-dioxo-1,2,3,4-tetrahydropyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-amino-1-benzyl-5-methyl(phenyl)carboxamido-2,3-dioxo-1,2,3,4-tetrahydropyrimidine

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Technology Process of 6-amino-1-benzyl-5-methyl(phenyl)carboxamido-2,3-dioxo-1,2,3,4-tetrahydropyrimidine

There total 3 articles about 6-amino-1-benzyl-5-methyl(phenyl)carboxamido-2,3-dioxo-1,2,3,4-tetrahydropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 98-88-4
benzoyl chloride

: 72816-88-7
6-amino-1-benzyl-5-N-methylaminouracil

: 1026890-84-5
6-amino-1-benzyl-5-methyl(phenyl)carboxamido-2,3-dioxo-1,2,3,4-tetrahydropyrimidine

Guidance literature:: With pyridine; In methanol; at 20 ℃; for 12h;
DOI:10.1021/jm011093d

Reference yield:

: 72816-87-6
6-amino-1-benzyl-5-bromo-2,4(1H)-pyrimidinedione

: 1026890-84-5
6-amino-1-benzyl-5-methyl(phenyl)carboxamido-2,3-dioxo-1,2,3,4-tetrahydropyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: H₂O / 4 h / 70 °C

2: 73 percent / pyridine / methanol / 12 h / 20 °C

With pyridine; In methanol; water;
DOI:10.1021/jm011093d

Reference yield:

: 538-32-9
benzylurea

: 1026890-84-5
6-amino-1-benzyl-5-methyl(phenyl)carboxamido-2,3-dioxo-1,2,3,4-tetrahydropyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic anhydride / 2 h / 80 °C

1.2: 1 h / 85 °C

2.1: sodium hydrogencarbonate; bromine / methanol / 0.5 h / 0 - 20 °C

2.2: 4 h / 70 °C

3.1: pyridine / dichloromethane / 16 h / 20 °C

With pyridine; bromine; acetic anhydride; sodium hydrogencarbonate; In methanol; dichloromethane;
DOI:10.1021/cb300426u