(E)-(6S,7S)-7-(4-Methoxy-benzyloxymethoxy)-4-methoxymethoxymethyl-7-((2R,4S,5R)-2-phenyl-5-triethylsilanyloxy-[1,3]dioxan-4-yl)-6-triethylsilanyloxy-hept-4-en-1-ol

Base Information

Chemical Name:(E)-(6S,7S)-7-(4-Methoxy-benzyloxymethoxy)-4-methoxymethoxymethyl-7-((2R,4S,5R)-2-phenyl-5-triethylsilanyloxy-[1,3]dioxan-4-yl)-6-triethylsilanyloxy-hept-4-en-1-ol
CAS No.:834916-76-6
Molecular Formula:C₄₁H₆₈O₁₀Si₂
Molecular Weight:777.156
Hs Code.:

(E)-(6S,7S)-7-(4-Methoxy-benzyloxymethoxy)-4-methoxymethoxymethyl-7-((2R,4S,5R)-2-phenyl-5-triethylsilanyloxy-[1,3]dioxan-4-yl)-6-triethylsilanyloxy-hept-4-en-1-ol

Synonyms:(E)-(6S,7S)-7-(4-Methoxy-benzyloxymethoxy)-4-methoxymethoxymethyl-7-((2R,4S,5R)-2-phenyl-5-triethylsilanyloxy-[1,3]dioxan-4-yl)-6-triethylsilanyloxy-hept-4-en-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-(6S,7S)-7-(4-Methoxy-benzyloxymethoxy)-4-methoxymethoxymethyl-7-((2R,4S,5R)-2-phenyl-5-triethylsilanyloxy-[1,3]dioxan-4-yl)-6-triethylsilanyloxy-hept-4-en-1-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (E)-(6S,7S)-7-(4-Methoxy-benzyloxymethoxy)-4-methoxymethoxymethyl-7-((2R,4S,5R)-2-phenyl-5-triethylsilanyloxy-[1,3]dioxan-4-yl)-6-triethylsilanyloxy-hept-4-en-1-ol

There total 9 articles about (E)-(6S,7S)-7-(4-Methoxy-benzyloxymethoxy)-4-methoxymethoxymethyl-7-((2R,4S,5R)-2-phenyl-5-triethylsilanyloxy-[1,3]dioxan-4-yl)-6-triethylsilanyloxy-hept-4-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R,4S,5R)-4-[(E)-(1S,2S)-7-(9-Bora-bicyclo[3.3.1]non-9-yl)-1-(4-methoxy-benzyloxymethoxy)-4-methoxymethoxymethyl-2-triethylsilanyloxy-hept-3-enyl]-2-phenyl-5-triethylsilanyloxy-[1,3]dioxane

: 834916-76-6
(E)-(6S,7S)-7-(4-Methoxy-benzyloxymethoxy)-4-methoxymethoxymethyl-7-((2R,4S,5R)-2-phenyl-5-triethylsilanyloxy-[1,3]dioxan-4-yl)-6-triethylsilanyloxy-hept-4-en-1-ol

Guidance literature:: With sodium hydroxide; dihydrogen peroxide; at 0 - 20 ℃;
DOI:10.1002/anie.200461802

Reference yield:

: 994-30-9
triethylsilyl chloride

: 834916-76-6
(E)-(6S,7S)-7-(4-Methoxy-benzyloxymethoxy)-4-methoxymethoxymethyl-7-((2R,4S,5R)-2-phenyl-5-triethylsilanyloxy-[1,3]dioxan-4-yl)-6-triethylsilanyloxy-hept-4-en-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / tetrahydrofuran / 40 °C

2: DIPEA; n-Bu₄NBr / CH₂Cl₂ / Heating

3: 89 percent / DIBAL-H / tetrahydrofuran / -78 °C

4: 95 percent / DIPEA; n-Bu₄NBr / 1,2-dichloro-ethane / 20 °C

5: tetrahydrofuran / 20 °C

6: aq. H₂O₂; NaOH / 0 - 20 °C

With sodium hydroxide; tetrabutylammomium bromide; dihydrogen peroxide; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1002/anie.200461802

Reference yield:

: 3006-41-5,20771-09-9,25152-90-3,97232-16-1,104022-77-7,113566-67-9,113566-68-0
4,6-O-benzylidene-D-glucose

: 834916-76-6
(E)-(6S,7S)-7-(4-Methoxy-benzyloxymethoxy)-4-methoxymethoxymethyl-7-((2R,4S,5R)-2-phenyl-5-triethylsilanyloxy-[1,3]dioxan-4-yl)-6-triethylsilanyloxy-hept-4-en-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran / Heating

2: Et₃N / tetrahydrofuran / 40 °C

3: DIPEA; n-Bu₄NBr / CH₂Cl₂ / Heating

4: 89 percent / DIBAL-H / tetrahydrofuran / -78 °C

5: 95 percent / DIPEA; n-Bu₄NBr / 1,2-dichloro-ethane / 20 °C

6: tetrahydrofuran / 20 °C

7: aq. H₂O₂; NaOH / 0 - 20 °C

With sodium hydroxide; tetrabutylammomium bromide; dihydrogen peroxide; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; 1: Wittig reaction;
DOI:10.1002/anie.200461802