N-{3-fluoro-4-[(6-(methyloxy)-7-{[(1-methylpiperidin-4-yl)methyl]oxy}quinazolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide hydrochloride

Base Information

Chemical Name:N-{3-fluoro-4-[(6-(methyloxy)-7-{[(1-methylpiperidin-4-yl)methyl]oxy}quinazolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide hydrochloride
CAS No.:849217-72-7
Molecular Formula:C₃₃H₃₃F₂N₅O₅*ClH
Molecular Weight:654.113
Hs Code.:

N-{3-fluoro-4-[(6-(methyloxy)-7-{[(1-methylpiperidin-4-yl)methyl]oxy}quinazolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide hydrochloride

Synonyms:N-{3-fluoro-4-[(6-(methyloxy)-7-{[(1-methylpiperidin-4-yl)methyl]oxy}quinazolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide hydrochloride

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Chemical Property of N-{3-fluoro-4-[(6-(methyloxy)-7-{[(1-methylpiperidin-4-yl)methyl]oxy}quinazolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide hydrochloride

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Technology Process of N-{3-fluoro-4-[(6-(methyloxy)-7-{[(1-methylpiperidin-4-yl)methyl]oxy}quinazolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide hydrochloride

There total 13 articles about N-{3-fluoro-4-[(6-(methyloxy)-7-{[(1-methylpiperidin-4-yl)methyl]oxy}quinazolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 849217-71-6
cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(piperidin-4-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-amide-(4-fluoro-phenyl)-amide trifluoroacetate

: 849217-72-7
N-{3-fluoro-4-[(6-(methyloxy)-7-{[(1-methylpiperidin-4-yl)methyl]oxy}quinazolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide hydrochloride

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In water; acetonitrile; at 20 ℃; for 1 - 2h;

Reference yield:

: 168268-00-6
4-(benzyloxy)-3-fluoroaniline

: 849217-72-7
N-{3-fluoro-4-[(6-(methyloxy)-7-{[(1-methylpiperidin-4-yl)methyl]oxy}quinazolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

2: cyclohexa-1,4-diene / palladium 10% on activated carbon / ethanol / 2 h / Heating / reflux

3: potassium carbonate / ISOPROPYLAMIDE / 16 h / 50 °C

4: hydrogen; acetic acid / palladium 10% on activated carbon / methanol; dichloromethane / 4 h / 2068.65 Torr

5: potassium carbonate / N,N-dimethyl-formamide / 80 °C

6: dichloromethane / 1 h / 20 °C

7: sodium tris(acetoxy)borohydride; acetic acid / water; acetonitrile / 1 - 2 h / 20 °C

With cyclohexa-1,4-diene; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 76243-24-8
1-(benzyloxy)-2-fluoro-4-nitrobenzene

: 849217-72-7
N-{3-fluoro-4-[(6-(methyloxy)-7-{[(1-methylpiperidin-4-yl)methyl]oxy}quinazolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: ammonium formate; iron / water; toluene / Heating / reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

3: cyclohexa-1,4-diene / palladium 10% on activated carbon / ethanol / 2 h / Heating / reflux

4: potassium carbonate / ISOPROPYLAMIDE / 16 h / 50 °C

5: hydrogen; acetic acid / palladium 10% on activated carbon / methanol; dichloromethane / 4 h / 2068.65 Torr

6: potassium carbonate / N,N-dimethyl-formamide / 80 °C

7: dichloromethane / 1 h / 20 °C

8: sodium tris(acetoxy)borohydride; acetic acid / water; acetonitrile / 1 - 2 h / 20 °C

With cyclohexa-1,4-diene; hydrogen; ammonium formate; sodium tris(acetoxy)borohydride; iron; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; toluene; acetonitrile;