717105-57-2

Usage

Physical state

Pale yellow liquid

Odor

Sweet, floral

Uses

Perfumes, fragrances, flavoring agent in food industry

Natural occurrence

Found in fruits and flowers

Medicinal properties

Antioxidant, potential use in cancer treatment

Versatility

Wide range of applications in various industries

Upstream product

• 23023-16-7 2‐(3,4‐dimethoxyphenyl)‐2‐methylpropionitrile 
• 70822-01-4 2-(3,4-dimethoxy-phenyl)-2-methyl-propan-1-ol 

Downstream Products

• 1239963-71-3 3-(3,4-dimethoxyphenyl)-3-methyl-1-nitrobutan-2-ol 
• 1430211-17-8 5-(2-((5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)ethoxy)-1H-indazole 
• 1430211-02-1 5-(2-((5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)ethoxy)-1H-indole 
• 1430210-74-4 5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-2-((2-(2-fluoro-4-(2-methyl-1H-imidazol-1-yl)phenoxy)ethyl)thio)-1-(4-fluorophenyl)-1H-imidazole 
• 1430210-73-3 5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-2-((2-(2-fluoro-4-(1H-imidazol-1-yl)phenoxy)ethyl)thio)-1-(4-fluorophenyl)-1H-imidazole 
• 1430210-67-5 5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-2-((2-(4-(2-methyl-1H-imidazol-1-yl)phenoxy)ethyl)thio)-1H-imidazole 
• 1430210-54-0 2-((2-(4-(1H-imidazol-1-yl)phenoxy)ethyl)thio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole 
• 1430210-68-6 1-(4-(2-((5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)ethoxy)phenyl)-1H-1,2,4-triazole 
• 1430210-71-1 1-(4-(2-((5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)ethoxy)phenyl)-1H-pyrazole 
• 1430210-53-9 2-((2-(4-(1H-pyrrol-1-yl)phenoxy)ethyl)thio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole 

Relevant academic research and scientific papers

A tandem annulation with a [1,3]-hydride transfer as the key step leading to isochromans

An unprecedented method that enables the direct coupling of an α-C-H bond in alcohols with 2-arylacetaldehydes through a [1,3]-hydride transfer ([1,3]-HT) of oxocarbenium ions catalyzed by a Lewis acid has been developed. The redox neutral preparation of

Discovery of a Potent and Orally Efficacious TGR5 Receptor Agonist

TGR5 is a G protein-coupled receptor (GPCR), activation of which promotes secretion of glucagon-like peptide-1 (GLP-1) and modulates insulin secretion. The 2-thio-imidazole derivative 6g was identified as a novel, potent, and selective TGR5 agonist (hTGR5

2-THIO-IMIDAZOLE DERIVATIVES AS TGR5 MODULATORS

The present invention relates to compounds of the general Formula I their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers, prodrugs, their N-oxide, metabolites, polymorphs, use of these compounds in medicine for treating diabetes (TGR5 modulators) and the intermediates involved in their preparation.

TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY

The present invention comprises TGR5 agonists of structural formula I, wherein X, R1, R2, and R5 are defined herein, as well as N-oxides of them and pharmaceutically acceptable salts thereof. The invention further comprise

ARYL-QUINAZOLINE/ARYL-2AMINO-PHENYL METHANONE DERIVATIVES

A compound of formula (I): wherein R1, R2, R3 and Y are as defined herein, or a pharmaceutically-acceptable and -cleavable ester, or acid addition salt thereof, useful for promoting the release of parathyroid hormone, e.g. for preventing or treating bone conditions which are associated with increased calcium depletion or resorption or in which stimulation of bone formation and calcium fixation in the bone is desirable.