Technology Process of (2S,4R)-6-Benzyloxy-5,5-dimethyl-hexane-1,2,4-triol
There total 17 articles about (2S,4R)-6-Benzyloxy-5,5-dimethyl-hexane-1,2,4-triol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
osmium(VIII) oxide; (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan); potassium carbonate; potassium hexacyanoferrate(III);
In
water; tert-butyl alcohol;
at 0 ℃;
Yield given. Yields of byproduct given;
DOI:10.3987/COM-95-S64
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 89 percent / CuI / tetrahydrofuran / -20 - 20 °C
2: N-methylmorpholine oxide, OsO4 / acetone; 2-methyl-propan-2-ol; H2O / Ambient temperature
With
copper(l) iodide; osmium(VIII) oxide; 4-methylmorpholine N-oxide;
In
tetrahydrofuran; water; acetone; tert-butyl alcohol;
DOI:10.3987/COM-95-S64
- Guidance literature:
-
Multi-step reaction with 8 steps
1: NaH
2: AcOH / H2O
3: NaH, p-TsCl
4: 99 percent / CuI / tetrahydrofuran / -23 deg C to room temperature
5: 1.) OsO4, NMO, 2.) NaIO4 / 1.) aq. acetone, t-BuOH, room temperature, 2.) aq. THF, room temperature
6: 67 percent / MsCl, Et3N, i-Pr2NEt / CH2Cl2 / Heating
7: CH2Cl2 / Ambient temperature
8: LiAlH4 / tetrahydrofuran / Heating
With
sodium periodate; copper(l) iodide; osmium(VIII) oxide; lithium aluminium tetrahydride; N-methyl-2-indolinone; sodium hydride; acetic acid; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; p-toluenesulfonyl chloride;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1016/0040-4039(94)88289-4
