6-<1-(4-bromophenyl)-1-propen-3-yl>-2,3-dihydro-5-benzofuranol

Base Information

• Chemical Name: 6-<1-(4-bromophenyl)-1-propen-3-yl>-2,3-dihydro-5-benzofuranol
• CAS No.: 124855-00-1
• Molecular Formula: C₁₇H₁₅BrO₂
• Molecular Weight: 331.209
• Mol file: 124855-00-1.mol

Synonyms:6-<1-(4-bromophenyl)-1-propen-3-yl>-2,3-dihydro-5-benzofuranol

Chemical Property of 6-<1-(4-bromophenyl)-1-propen-3-yl>-2,3-dihydro-5-benzofuranol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-<1-(4-bromophenyl)-1-propen-3-yl>-2,3-dihydro-5-benzofuranol

There total 3 articles about 6-<1-(4-bromophenyl)-1-propen-3-yl>-2,3-dihydro-5-benzofuranol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (E)-3-(4-bromophenyl)-2-propenoate (24393-53-1,136265-11-7,15795-20-7) → 6-<1-(4-bromophenyl)-1-propen-3-yl>-2,3-dihydro-5-benzofuranol (124855-00-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / diisobutylaluminium hydride / toluene / Ambient temperature

2: 86 percent / PBr₃ / CCl₄ / -20 - 10 °C

3: 1.) NaH / 1.) benzene, 90 min, 2.) 75 deg C

With phosphorus tribromide; sodium hydride; diisobutylaluminium hydride; In tetrachloromethane; toluene;

Reference yield:

(2E)-3-(4-bromophenyl)prop-2-en-1-ol (105515-33-1) → 6-<1-(4-bromophenyl)-1-propen-3-yl>-2,3-dihydro-5-benzofuranol (124855-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / PBr₃ / CCl₄ / -20 - 10 °C

2: 1.) NaH / 1.) benzene, 90 min, 2.) 75 deg C

With phosphorus tribromide; sodium hydride; In tetrachloromethane;

Reference yield:

2,3-dihydrobenzofuran-5-ol (40492-52-2) + 1-(4-bromophenyl)-1-propen-3-yl bromide (96090-12-9,124854-99-5) → 6-<1-(4-bromophenyl)-1-propen-3-yl>-2,3-dihydro-5-benzofuranol (124855-00-1)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) benzene, 90 min, 2.) 75 deg C;

upstream raw materials:

2,3-dihydrobenzofuran-5-ol

1-(4-bromophenyl)-1-propen-3-yl bromide

ethyl (E)-3-(4-bromophenyl)-2-propenoate

(2E)-3-(4-bromophenyl)prop-2-en-1-ol

Downstream raw materials:

(E)-6-<1-(4-cyanophenyl)-1-propen-3-yl>-2,3-dihydro-5-benzofuranol methoxymethyl ether

6-<1-(4-acetylphenyl)-1-propen-3-yl>-2,3-dihydro-5-benzofuranol

6-<1-(4-cyanophenyl)-1-propen-3-yl>-2,3-dihydro-5-benzofuranol