40492-52-2

Usage

Uses

Used in Fragrance and Perfume Industry:
2,3-dihydro-benzofuran-5-ol is used as a fragrance ingredient for its pleasant scent, contributing to the creation of various perfumes and fragrances.
Used in Food Industry:
In the food industry, 2,3-dihydro-benzofuran-5-ol is utilized as a flavoring agent, enhancing the taste and aroma of different food products.
Used in Pharmaceutical Industry:
2,3-dihydro-benzofuran-5-ol has potential applications in pharmaceuticals, likely due to its aromatic properties, which could be harnessed for the development of medicinal compounds.
Used in Cosmetics Industry:
Similarly, in cosmetics, this chemical is used for its aromatic qualities, potentially in the formulation of scented products such as lotions, creams, and other beauty formulations.
Safety Note:
It is important to handle 2,3-dihydro-benzofuran-5-ol with care, as it can cause skin and eye irritation upon contact, necessitating proper safety measures during its use in various applications.

InChI:InChI=1/C8H8O2/c9-7-1-2-8-6(5-7)3-4-10-8/h1-2,5,9H,3-4H2

Upstream product

• 64010-12-4 2-bromophenyl 2-chloroethyl ether 
• 13196-10-6 benzofuran-5-ol 
• 13391-28-1 5-methoxybenzofuran 
• 150-76-5 4-methoxy-phenol 
• 17332-11-5 2-bromo-4-methoxyphenol 
• 76429-64-6 2-bromo-1-(2-bromoethoxy)-4-methoxybenzene 
• 4082-30-8 2-(2'-hydroxyethyl)-1,4-benzoquinone 
• 55745-70-5 2,3-dihydro-benzofuran-5-carbaldehyde 
• 90843-31-5 1-(2,3-dihydrobenzofuran-5-yl)ethanone 
• 13391-30-5 2,3-dihydro-5-methoxybenzofuran 
• 99187-42-5 2-(2,5-dimethoxyphenyl)ethylbromide 
• 1758-25-4 (2,5-dimethoxyphenyl)acetic acid 
• 7417-19-8 2-(2,5-dimethoxyphenyl)ethanol 
• 496-16-2 2.3-dihydrobenzofuran 

Downstream Products

• 124855-00-1 6-<1-(4-bromophenyl)-1-propen-3-yl>-2,3-dihydro-5-benzofuranol 
• 124854-96-2 6-<3-(2-Bromophenyl)-2-propenyl>-2,3-dihydro-5-hydroxybenzofuran 
• 40492-53-3 2,3-dihydro-6-bromo-5-hydroxybenzofuran 
• 557-40-4 Allyl ether 
• 1431793-76-8 6-(2,4-dimethoxyphenyl)-4-(2,4,6-trimethoxyphenyl)-2,3-dihydrobenzofuran-5-ol 
• 1314579-23-1 2,3-dihydro-6-(2',4'-dimethoxyphenyl)-5-benzofuranol 
• 1431793-61-1 C₁₇H₁₈O₅ 
• 99385-88-3 5-hydroxy-2,3-dihydrobenzofuran-6-carboxaldehyde 
• 120694-96-4 6-(3-(2-hydroxymethylphenyl)-trans-prop-2-enyl)-5-hydroxy-2,3-dihydrobenzofuran 
• 126080-77-1 2,3-Dihydro-5-hydroxy-6-<3-(2-methoxycarbonylphenyl)-2-propenyl>benzofuran 
• 124854-97-3 6-<3-(2-Cyanophenyl)-2-propenyl>-2,3-dihydro-5-hydroxybenzofuran 

Relevant academic research and scientific papers

2,3-dihydrobenzofuran analogues of hallucinogenic phenethylamines

Two 2,3-dihydrobenzofuran analogues of hallucinogenic amphetamines were prepared and evaluated for activity in the two-lever drug-discrimination paradigm in rats trained to discriminate saline from LSD tartrate (0.08 mg/kg) and for the ability to displace [125I]-(R)-DOI ([125I]-(R)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane) from rat cortical homogenate 5-HT2 receptors. The compounds, 1-(5-methoxy-2,3-dihydrobenzofuran-4-yl)-2-aminopropane (6a) and its 7-brominated analogue 6b, possessed activity comparable to their conformationally flexible counterparts 1-(2,5-dimethoxyphenyl)-2-aminopropane (3) and its 4-bromo derivative DOB (5), respectively. The results suggest that the dihydrofuran ring in 6a and 6b models the active conformation of the 5-methoxy groups in 3 and 5. Free energy of binding, derived from radioligand displacement K(A) values, indicated that addition of the bromine in either series contributes 2.4-3.2 kcal/mol of binding energy. On the basis of surface area of the bromine atom, this value is 2-3 times higher than would be expected on the basis of hydrophobic binding. Thus, hydrophobicity of the para substituent alone cannot account for the dramatic enhancement of hallucinogenic activity. Although this substituent may play a minor role in orienting the conformation of the 5-methoxy group in derivatives such as 4 and 5, there appears to be some other, as yet unknown, critical receptor interaction.

PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY ARYL COMPOUNDS

The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (I).

Para -Selective hydroxylation of alkyl aryl ethers

para-Selective hydroxylation of alkyl aryl ethers is established, which proceeds with a ruthenium(ii) catalyst, hypervalent iodine(iii) and trifluoroacetic anhydride via a radical mechanism. This protocol tolerates a wide scope of substrates and provides a facile and efficient method for preparing clinical drugs monobenzone and pramocaine on a gram scale.

HEMOGLOBIN MODIFIER COMPOUNDS AND USES THEREOF

Described herein are compounds, including pharmaceutically acceptable salts thereof, methods of making such compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat, prevent or diagnose blood-based diseases, disorders or conditions.

PYRAZINES AS DELTA OPIOID RECEPTOR MODULATORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, L, X, and Y are defined herein.

SUBSTITUTED ALKYNYL PHENOXY COMPOUNDS AS NEW SYNERGISTS IN PESTICIDAL COMPOSITIONS

A composition comprising an alkynyl phenoxy compound of Formula (I) as a synergist and a pesticidal active ingredient is described, wherein R1 and R2, similar or different, are (C1-C4)alkyl or R1O- an

Substituted alkynyl phenoxy compounds and their uses

An alkynyl phenoxy compound of Formula (I) is described, wherein R1 and R2, similar or different, are (C1-C4)alkyl or R1O- and R2O- together represent a group -O-CH2-O-, -O-CH(CH

INHIBITORS OF ACETYL-COA CARBOXYLASE

The present invention relates to compounds that act as acetyl-CoA carboxylase (ACC) inhibitors. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

Therapeutic diphenyl ether ligands

This invention is directed to compounds of formula Ia, Ib or Ic and to pharmaceutical compositions thereof: or a prodrug thereof and a pharmaceutically acceptable carrier, wherein the R groups are defined in the specification; and, in which the dashed line represents an optional double bond. The invention is also directed to methods of treating, diagnosing, and preventing disorders of the central nervous system that are associated with 5HT receptors, including obesity, attention deficit disorder, migraine, depression, epilepsy, anxiety, Alzheimer's disease, withdrawal from drug abuse, pain, schizophrenia, stress-related disorders, panic disorder, sleep disorders, phobias, obsessive compulsive disorder, post-traumatic-stress syndrome, immune system depression, stress-induced gastrointestinal dysfunction, stress-induced cardiovascular dysfunction, and sexual dysfunction.

Formal Radical Cyclization onto Benzene Rings: A General Method and Its Use in the Synthesis of ent-Nocardione A

An indirect method is described for effecting radical cyclization onto a benzene ring. Cross-conjugated dienones 6, which are readily prepared from phenols, undergo radical cyclization (6 → 7 → 8), and the products (8) are easily aromatized. The method ha