2,3-Dihydrobenzofuran-5-ol

Base Information

• Chemical Name: 2,3-Dihydrobenzofuran-5-ol
• CAS No.: 40492-52-2
• Molecular Formula: C8H8O2
• Molecular Weight: 136.15
• Hs Code.: 2932999099
• European Community (EC) Number: 692-470-4
• DSSTox Substance ID: DTXSID10456059
• Nikkaji Number: J859.887H
• Wikidata: Q72465118
• ChEMBL ID: CHEMBL7696
• Mol file: 40492-52-2.mol

Synonyms:2,3-dihydrobenzofuran-5-ol;40492-52-2;2,3-Dihydro-1-benzofuran-5-ol;2,3-Dihydro-benzofuran-5-ol;5-hydroxy-2,3-dihydrobenzofuran;5-Benzofuranol, 2,3-dihydro-;2,3-dihydrobenzo[b]furan-5-ol;2,3-dihydro-5-benzofuranol;CHEMBL7696;SCHEMBL281830;2,3-dihydro-5-hydroxybenzofuran;DTXSID10456059;JNYKOGUXPNAUIB-UHFFFAOYSA-N;CS-B1237;2,3-Dihydro-5-hydroxybenzo[b]furan;MFCD09029838;AKOS006280763;AB92783;PS-5081;AC-17800;BB 0261052;FT-0681606;EN300-343814;Not available;2,3-Dihydro-5-hydroxybenzofuran;A873323;J-507011;F2185-1890;Z1198182902

Chemical Property of 2,3-Dihydrobenzofuran-5-ol

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.607
• Boiling Point: 287.446 °C at 760 mmHg
• PKA: 10.55±0.20(Predicted)
• Flash Point: 143.65 °C
• PSA: 29.46000
• Density: 1.261 g/cm³
• LogP: 1.32710
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 136.052429494
• Heavy Atom Count: 10
• Complexity: 124

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,3-dihydrobenzofuran-5-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC2=C1C=C(C=C2)O

Technology Process of 2,3-Dihydrobenzofuran-5-ol

There total 26 articles about 2,3-Dihydrobenzofuran-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-(2'-hydroxyethyl)-1,4-benzoquinone (4082-30-8) → 2,3-dihydrobenzofuran-5-ol (40492-52-2)

Guidance literature:

With 2-cyclohexene-1,4-dione; pyridinium p-toluenesulfonate; In toluene; for 3h; Heating;

DOI:10.1021/jo000696e

Reference yield: 51.0%

benzofuran-5-ol (13196-10-6) → 2,3-dihydrobenzofuran-5-ol (40492-52-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; for 19h; under 2585.81 Torr;

Reference yield: 38.0%

2,3-dihydro-5-methoxybenzofuran (13391-30-5) → 2,3-dihydrobenzofuran-5-ol (40492-52-2)

Guidance literature:

With boron tribromide; In dichloromethane; at -60 - 20 ℃; for 17h;

upstream raw materials:

5-bromo-2,3-dihydrobenzo[b]furan

2-(2-bromoethyl)-1,4-dihydroquinone

2,3-Dihydro-5-benzofuranyl allyl ether

2-(2'-hydroxyethyl)-1,4-benzoquinone

Downstream raw materials:

6-<1-(4-bromophenyl)-1-propen-3-yl>-2,3-dihydro-5-benzofuranol

6-<3-(2-Bromophenyl)-2-propenyl>-2,3-dihydro-5-hydroxybenzofuran

2,3-dihydro-6-bromo-5-hydroxybenzofuran

5-hydroxy-2,3-dihydrobenzofuran-6-carboxaldehyde

Refernces

• 1、 Zhu, Runqing,Sun, Qianqian,Li, Jing,Li, Luohao,Gao, Qinghe,Wang, Yakun,Fang, Lizhen. "Para -Selective hydroxylation of alkyl aryl ethers". supporting information. p. 13190 - 13193. Retrieved 2021/12/16.
• 2、 -. "HEMOGLOBIN MODIFIER COMPOUNDS AND USES THEREOF". Paragraph 00384. . Retrieved 2018/02/28.