2-[(E/Z)-2-(4-bromophenyl)vinyl]-3-carboxy-5-chloropyridinium chloride

Base Information

Chemical Name:2-[(E/Z)-2-(4-bromophenyl)vinyl]-3-carboxy-5-chloropyridinium chloride
CAS No.:917882-51-0
Molecular Formula:C₁₄H₉BrClNO₂*ClH
Molecular Weight:375.049
Hs Code.:

Synonyms:2-[(E/Z)-2-(4-bromophenyl)vinyl]-3-carboxy-5-chloropyridinium chloride

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Chemical Property of 2-[(E/Z)-2-(4-bromophenyl)vinyl]-3-carboxy-5-chloropyridinium chloride

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Technology Process of 2-[(E/Z)-2-(4-bromophenyl)vinyl]-3-carboxy-5-chloropyridinium chloride

There total 2 articles about 2-[(E/Z)-2-(4-bromophenyl)vinyl]-3-carboxy-5-chloropyridinium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 350597-49-8
2-methyl-5-chloro methylnicotinate

: 917882-51-0
2-[(E/Z)-2-(4-bromophenyl)vinyl]-3-carboxy-5-chloropyridinium chloride

Guidance literature:: 4-bromo-benzaldehyde; 2-methyl-5-chloro methylnicotinate; With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

With hydrogenchloride; water; In tetrahydrofuran; for 0.5h;

With ethanol; In tetrahydrofuran; for 4h;

Reference yield:

: methyl 2-[2-(4-bromophenyl)vinyl]-5-chloropyridine-3-carboxylate

: 917882-51-0
2-[(E/Z)-2-(4-bromophenyl)vinyl]-3-carboxy-5-chloropyridinium chloride

Guidance literature:: With hydrogenchloride; In ethanol; water; for 4.5h;

Reference yield:

: 917882-51-0
2-[(E/Z)-2-(4-bromophenyl)vinyl]-3-carboxy-5-chloropyridinium chloride

: 2-{[(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)amino]carbonyl}benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: PPA / 12 h / 20 °C

1.2: pH 10

2.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 2.08 h / 100 °C

3.1: trifluoroacetic acid / methanol; chloroform / 1 h / 20 °C

With PPA; trifluoroacetic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; methanol; chloroform;