N-acetoxy-6-{5-[4-(N-acetoxycarbamimidoyl)benzyl]furan-2-yl}nicotinamidine

Base Information

Chemical Name:N-acetoxy-6-{5-[4-(N-acetoxycarbamimidoyl)benzyl]furan-2-yl}nicotinamidine
CAS No.:619334-83-7
Molecular Formula:C₂₂H₂₁N₅O₅
Molecular Weight:435.439
Hs Code.:

Synonyms:N-acetoxy-6-{5-[4-(N-acetoxycarbamimidoyl)benzyl]furan-2-yl}nicotinamidine

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Chemical Property of N-acetoxy-6-{5-[4-(N-acetoxycarbamimidoyl)benzyl]furan-2-yl}nicotinamidine

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Technology Process of N-acetoxy-6-{5-[4-(N-acetoxycarbamimidoyl)benzyl]furan-2-yl}nicotinamidine

There total 5 articles about N-acetoxy-6-{5-[4-(N-acetoxycarbamimidoyl)benzyl]furan-2-yl}nicotinamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 108-24-7
acetic anhydride

: 619334-82-6
N-hydroxy-6-{5-[4-(N-hydroxycarbamimidoyl)benzyl]furan-2-yl}nicotinamidine

: 619334-83-7
N-acetoxy-6-{5-[4-(N-acetoxycarbamimidoyl)benzyl]furan-2-yl}nicotinamidine

Guidance literature:: With acetic acid;
DOI:10.1021/jm0302602

Reference yield:

: 33252-28-7
6-chloronicotinonitrile

: 619334-83-7
N-acetoxy-6-{5-[4-(N-acetoxycarbamimidoyl)benzyl]furan-2-yl}nicotinamidine

Guidance literature:: Multi-step reaction with 5 steps

1: 80.6 percent / tetrakis(triphenylphosphine)palladium / dioxane / 24 h / 100 - 110 °C

2: 90.4 percent / N-bromosuccinimide / dimethylformamide / 20 °C

3: 48 percent / tetrakis(triphenylphosphine)palladium / tetrahydrofuran / 24 h / 20 °C

4: 85 percent / hydroxylamine hydrochloride; potassium t-butoxide / dimethylsulfoxide / 20 °C

5: 98 percent / AcOH

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; potassium tert-butylate; acetic acid; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Stille coupling / 3: Negishi coupling;
DOI:10.1021/jm0302602

Reference yield:

: 619334-28-0
6-(furan-2-yl)nicotinonitrile

: 619334-83-7
N-acetoxy-6-{5-[4-(N-acetoxycarbamimidoyl)benzyl]furan-2-yl}nicotinamidine

Guidance literature:: Multi-step reaction with 4 steps

1: 90.4 percent / N-bromosuccinimide / dimethylformamide / 20 °C

2: 48 percent / tetrakis(triphenylphosphine)palladium / tetrahydrofuran / 24 h / 20 °C

3: 85 percent / hydroxylamine hydrochloride; potassium t-butoxide / dimethylsulfoxide / 20 °C

4: 98 percent / AcOH

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; potassium tert-butylate; acetic acid; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; 2: Negishi coupling;
DOI:10.1021/jm0302602