2-(4-benzyloxyphenyl)-8-(tert-butyldimethylsilanyloxymethyl)-1-ethylindolizine

Base Information

Chemical Name:2-(4-benzyloxyphenyl)-8-(tert-butyldimethylsilanyloxymethyl)-1-ethylindolizine
CAS No.:217303-25-8
Molecular Formula:C₃₀H₃₇NO₂Si
Molecular Weight:471.715
Hs Code.:

Synonyms:2-(4-benzyloxyphenyl)-8-(tert-butyldimethylsilanyloxymethyl)-1-ethylindolizine

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Chemical Property of 2-(4-benzyloxyphenyl)-8-(tert-butyldimethylsilanyloxymethyl)-1-ethylindolizine

Chemical Property:

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Technology Process of 2-(4-benzyloxyphenyl)-8-(tert-butyldimethylsilanyloxymethyl)-1-ethylindolizine

There total 6 articles about 2-(4-benzyloxyphenyl)-8-(tert-butyldimethylsilanyloxymethyl)-1-ethylindolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 217303-24-7
1-ethyl-2-(4-benzyloxyphenyl)-8-hydroxymethylindolizine

: 217303-25-8
2-(4-benzyloxyphenyl)-8-(tert-butyldimethylsilanyloxymethyl)-1-ethylindolizine

Guidance literature:: DOI:10.1016/S0960-894X(00)00474-1

Reference yield:

: 31931-49-4
ethyl 2-propylpyridine-3-carboxylate

: 217303-25-8
2-(4-benzyloxyphenyl)-8-(tert-butyldimethylsilanyloxymethyl)-1-ethylindolizine

Guidance literature:: Multi-step reaction with 3 steps

1.1: LiAlH₄ / tetrahydrofuran / 3 h / 25 °C

2.1: acetone / Heating

2.2: aq. NaHCO₃ / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran; acetone; 1.1: Reduction / 2.1: quaternization / 2.2: Cyclization / 3.1: silylation;
DOI:10.1016/S0960-894X(00)00474-1

Reference yield:

: 3249-68-1
ethyl butyroyl acetate

: 217303-25-8
2-(4-benzyloxyphenyl)-8-(tert-butyldimethylsilanyloxymethyl)-1-ethylindolizine

Guidance literature:: Multi-step reaction with 5 steps

1.1: NH₃ / diethyl ether / 8 h / 25 °C

2.1: piperidin / ethanol / 3 h / Heating

2.2: sulphur / 3 h / 150 °C

3.1: LiAlH₄ / tetrahydrofuran / 3 h / 25 °C

4.1: acetone / Heating

4.2: aq. NaHCO₃ / Heating

With piperidine; lithium aluminium tetrahydride; ammonia; In tetrahydrofuran; diethyl ether; ethanol; acetone; 1.1: Condensation / 2.1: Addition / 2.2: Cyclization / 3.1: Reduction / 4.1: quaternization / 4.2: Cyclization / 5.1: silylation;
DOI:10.1016/S0960-894X(00)00474-1