Succinic acid mono-[(2R,3S,6R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-6-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-pyran-3-yl] ester

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Chemical Name:Succinic acid mono-[(2R,3S,6R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-6-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-pyran-3-yl] ester
CAS No.:145610-82-8
Molecular Formula:C₃₅H₃₆N₂O₁₀
Molecular Weight:644.678
Hs Code.:

Succinic acid mono-[(2R,3S,6R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-6-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-pyran-3-yl] ester

Synonyms:Succinic acid mono-[(2R,3S,6R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-6-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-pyran-3-yl] ester

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Chemical Property of Succinic acid mono-[(2R,3S,6R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-6-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-pyran-3-yl] ester

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Technology Process of Succinic acid mono-[(2R,3S,6R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-6-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-pyran-3-yl] ester

There total 7 articles about Succinic acid mono-[(2R,3S,6R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-6-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-pyran-3-yl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 108-30-5
succinic acid anhydride

: 145593-98-2
1-<2',3'-Dideoxy-6'-<(4,4'-dimethoxytriphenyl)methyl>-β-D-glucopyranosyl>uracil

: 145610-82-8
Succinic acid mono-[(2R,3S,6R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-6-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-pyran-3-yl] ester

Guidance literature:: With pyridine; dmap; for 20h; Ambient temperature;
DOI:10.1002/hlca.19920750503

Reference yield:

: 3427-20-1
methyl 4,6-di-O-acetyl-2,3-dideoxy-D-erythro-hex-2-enopyranoside

: 145610-82-8
Succinic acid mono-[(2R,3S,6R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-6-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-pyran-3-yl] ester

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / H₂, AcOH / 10percent Pd/C / methanol / 8 h / Ambient temperature

2: 60 percent / 1a) hexamethyldisilazane, 1b) chlorotrimethylsilane, 2) SnCl₄ / acetonitrile / 1) r.t., 30 min, 2) 44 deg C, 16 h

3: 88 percent / NH₃ / methanol / 12 h / Ambient temperature

4: 87.4 percent / 4-(dimethylamino)pyridine, pyridine, Et₃N / 3 h / Ambient temperature

5: 78 percent / 4-(dimethylamino)pyridine, pyridine / 20 h / Ambient temperature

With pyridine; dmap; chloro-trimethyl-silane; ammonia; hydrogen; tin(IV) chloride; acetic acid; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; palladium on activated charcoal; In methanol; acetonitrile;
DOI:10.1002/hlca.19920750503

Reference yield:

: 2873-29-2
D-glucal triacetate

: 145610-82-8
Succinic acid mono-[(2R,3S,6R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-6-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-pyran-3-yl] ester

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / BF₃*Et₂O / toluene / 40 h / 5 deg C - r.t.

2: 82 percent / H₂, AcOH / 10percent Pd/C / methanol / 8 h / Ambient temperature

3: 60 percent / 1a) hexamethyldisilazane, 1b) chlorotrimethylsilane, 2) SnCl₄ / acetonitrile / 1) r.t., 30 min, 2) 44 deg C, 16 h

4: 88 percent / NH₃ / methanol / 12 h / Ambient temperature

5: 87.4 percent / 4-(dimethylamino)pyridine, pyridine, Et₃N / 3 h / Ambient temperature

6: 78 percent / 4-(dimethylamino)pyridine, pyridine / 20 h / Ambient temperature

With pyridine; dmap; chloro-trimethyl-silane; boron trifluoride diethyl etherate; ammonia; hydrogen; tin(IV) chloride; acetic acid; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; palladium on activated charcoal; In methanol; toluene; acetonitrile;
DOI:10.1002/hlca.19920750503