Ethyl 4-(3-chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylate

Base Information

Chemical Name:Ethyl 4-(3-chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylate
CAS No.:1231208-98-2
Molecular Formula:C₂₀H₁₃ClFNO₃
Molecular Weight:369.78
Hs Code.:

Synonyms:Ethyl 4-(3-chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylate

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Chemical Property of Ethyl 4-(3-chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylate

Chemical Property:

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Technology Process of Ethyl 4-(3-chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylate

There total 3 articles about Ethyl 4-(3-chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1231208-95-9
Ethyl 4-bromo-5-(3-cyanophenyl)furan-2-carboxylate

: 328956-61-2
3-fluoro-5-chlorophenylboronic acid

: 1231208-98-2
Ethyl 4-(3-chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylate

Guidance literature:: With caesium carbonate; XPhos; palladium diacetate; In 1,2-dimethoxyethane; at 50 ℃; Inert atmosphere;

Reference yield:

: 54113-42-7
2,3-dibromo-5-(ethoxycarbonyl)furan

: 1231208-98-2
Ethyl 4-(3-chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; XPhos / palladium diacetate / 1,2-dimethoxyethane / 20 °C / Inert atmosphere

2: caesium carbonate; XPhos / palladium diacetate / 1,2-dimethoxyethane / 50 °C / Inert atmosphere

With caesium carbonate; XPhos; palladium diacetate; In 1,2-dimethoxyethane; 1: Suzuki Coupling / 2: Suzuki Coupling;

Reference yield:

: 2434-03-9
4,5-dibromo-2-furoic acid

: 1231208-98-2
Ethyl 4-(3-chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / ethanol / Reflux

2: caesium carbonate; XPhos / palladium diacetate / 1,2-dimethoxyethane / 20 °C / Inert atmosphere

3: caesium carbonate; XPhos / palladium diacetate / 1,2-dimethoxyethane / 50 °C / Inert atmosphere

With sulfuric acid; caesium carbonate; XPhos; palladium diacetate; In 1,2-dimethoxyethane; ethanol; 2: Suzuki Coupling / 3: Suzuki Coupling;