Boc-Val-Cit-PAB-PNP

Base Information

• Chemical Name: Boc-Val-Cit-PAB-PNP
• CAS No.: 870487-10-8
• Molecular Formula: C₃₀H₄₀N₆O₁₀
• Molecular Weight: 644.682
• Mol file: 870487-10-8.mol

Synonyms:tert-butyl ((5)-3-methyl-1-(((5)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-1-oxobutan-2-yl)carbamate

Chemical Property of Boc-Val-Cit-PAB-PNP

Chemical Property:

• Boiling Point: 896.0±65.0 °C(Predicted)
• PKA: 11.25±0.46(Predicted)
• Density: 1.291±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

Boc-Val-Cit-PABC-PNP 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Boc-Val-Cit-PAB-PNB is a cleavable peptide ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell.PNP can be substituted by amine bearing molecules.

Technology Process of Boc-Val-Cit-PAB-PNP

There total 10 articles about Boc-Val-Cit-PAB-PNP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

tert-butyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentane-2-yl)amino)-3-methyl-1-oxobutane-2-yl)carbamate (870487-09-5) + bis-(p-nitrophenyl) carbonate (5070-13-3) → tert-butyl ((5)-3-methyl-1-(((5)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-1-oxobutan-2-yl)carbamate (870487-10-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

Reference yield: 70.0%

tert-butyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentane-2-yl)amino)-3-methyl-1-oxobutane-2-yl)carbamate (870487-09-5) + 4-Nitrophenyl chloroformate (7693-46-1) → tert-butyl ((5)-3-methyl-1-(((5)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-1-oxobutan-2-yl)carbamate (870487-10-8)

Guidance literature:

With pyridine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 3h;

Reference yield:

tert-butyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentane-2-yl)amino)-3-methyl-1-oxobutane-2-yl)carbamate (870487-09-5) + 4-Nitrophenyl chloroformate (7693-46-1) → tert-butyl ((5)-3-methyl-1-(((5)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-1-oxobutan-2-yl)carbamate (870487-10-8) + C47H72N10O13

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; at -20 ℃;

upstream raw materials:

tert-butyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentane-2-yl)amino)-3-methyl-1-oxobutane-2-yl)carbamate

4-Nitrophenyl chloroformate

(6S,9S)-1-amino-9-isopropyl-13,13-dimethyl-1,8,11-trioxo-12-oxa-2,7,10-triazatetradecane-6-carboxylic acid

bis-(p-nitrophenyl) carbonate

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