(R)-3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-2-methylpropanoic acid

Base Information

Chemical Name:(R)-3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-2-methylpropanoic acid
CAS No.:1309366-06-0
Molecular Formula:C₂₄H₂₈N₂O₂
Molecular Weight:376.499
Hs Code.:

Synonyms:(R)-3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-2-methylpropanoic acid

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Chemical Property of (R)-3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-2-methylpropanoic acid

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Technology Process of (R)-3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-2-methylpropanoic acid

There total 7 articles about (R)-3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl 3-(6-bromo-2-(tert-butylamino)quinolin-3-yl)-2-methylacrylate

: 1309366-06-0
(R)-3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); water; potassium acetate / ethanol / 2 h / 80 °C / Inert atmosphere

2: palladium on activated charcoal; hydrogen / methanol / Inert atmosphere

3: methanol; sodium hydroxide / 2 h / Reflux; Inert atmosphere

4: chiralcel OJ-H / methanol; carbon dioxide; isopropylamine / Resolution of racemate; liquid CO₂

With methanol; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); palladium on activated charcoal; water; hydrogen; potassium acetate; sodium hydroxide; In methanol; ethanol; carbon dioxide; isopropylamine;
DOI:10.1021/jm200544q

Reference yield:

: 1321992-43-1
ethyl 3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-2-methylacrylate

: 1309366-06-0
(R)-3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: palladium on activated charcoal; hydrogen / methanol / Inert atmosphere

2: methanol; sodium hydroxide / 2 h / Reflux; Inert atmosphere

3: chiralcel OJ-H / methanol; carbon dioxide; isopropylamine / Resolution of racemate; liquid CO₂

With methanol; palladium on activated charcoal; hydrogen; sodium hydroxide; In methanol; carbon dioxide; isopropylamine;
DOI:10.1021/jm200544q

Reference yield:

: 1309366-04-8
ethyl 3‐[2‐(tert‐butylamino)‐6‐(2‐methylphenyl)quinolin‐3‐yl]‐2‐methylpropanoate

: 1309366-06-0
(R)-3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; sodium hydroxide / 2 h / Reflux; Inert atmosphere

2: chiralcel OJ-H / methanol; carbon dioxide; isopropylamine / Resolution of racemate; liquid CO₂

With methanol; sodium hydroxide; In methanol; carbon dioxide; isopropylamine;
DOI:10.1021/jm200544q