ethyl 3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-2-methylacrylate

Base Information

Chemical Name:ethyl 3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-2-methylacrylate
CAS No.:1321992-43-1
Molecular Formula:C₂₆H₃₀N₂O₂
Molecular Weight:402.536
Hs Code.:

Synonyms:

Suppliers and Price of ethyl 3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-2-methylacrylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-2-methylacrylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-2-methylacrylate

There total 3 articles about ethyl 3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-2-methylacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1308870-06-5
2-(tert-butylamino)-6-bromoquinoline-3-carbaldehyde

: 1321992-43-1
ethyl 3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-2-methylacrylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 10 h / 20 °C / Inert atmosphere

2: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); water; potassium acetate / ethanol / 2 h / 80 °C / Inert atmosphere

With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); water; potassium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In ethanol; acetonitrile; 1: Wittig reaction;
DOI:10.1021/jm200544q

Reference yield:

: 103-88-8
4-bromoacetanilide

: 1321992-43-1
ethyl 3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-2-methylacrylate

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 48 h / 75 °C / Inert atmosphere

2: 1-methyl-pyrrolidin-2-one / 24 h / 130 °C / Inert atmosphere

3: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 10 h / 20 °C / Inert atmosphere

4: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); water; potassium acetate / ethanol / 2 h / 80 °C / Inert atmosphere

With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); water; potassium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; ethanol; acetonitrile; 1: Vilsmeier-Haack reaction / 1: Vilsmeier-Haack reaction / 3: Wittig reaction;
DOI:10.1021/jm200544q

Reference yield:

: 73568-35-1
6-bromo-2-chloro-3-formylquinoline

: 1321992-43-1
ethyl 3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-2-methylacrylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1-methyl-pyrrolidin-2-one / 24 h / 130 °C / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 10 h / 20 °C / Inert atmosphere

3: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); water; potassium acetate / ethanol / 2 h / 80 °C / Inert atmosphere

With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); water; potassium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In 1-methyl-pyrrolidin-2-one; ethanol; acetonitrile; 2: Wittig reaction;
DOI:10.1021/jm200544q