N'-[1-(3-Cyano-phenyl)-meth-(E)-ylidene]-hydrazinecarboxylic acid tert-butyl ester

Base Information

• Chemical Name: N'-[1-(3-Cyano-phenyl)-meth-(E)-ylidene]-hydrazinecarboxylic acid tert-butyl ester
• CAS No.: 386768-80-5
• Molecular Formula: C₁₃H₁₅N₃O₂
• Molecular Weight: 245.281
• Mol file: 386768-80-5.mol

Synonyms:N'-[1-(3-Cyano-phenyl)-meth-(E)-ylidene]-hydrazinecarboxylic acid tert-butyl ester

Chemical Property of N'-[1-(3-Cyano-phenyl)-meth-(E)-ylidene]-hydrazinecarboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-[1-(3-Cyano-phenyl)-meth-(E)-ylidene]-hydrazinecarboxylic acid tert-butyl ester

There total 1 articles about N'-[1-(3-Cyano-phenyl)-meth-(E)-ylidene]-hydrazinecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

t-butoxycarbonylhydrazine (870-46-2) + 3-Cyanobenzaldehyde (24964-64-5) → N'-[1-(3-Cyano-phenyl)-meth-(E)-ylidene]-hydrazinecarboxylic acid tert-butyl ester (386768-80-5)

Guidance literature:

In ethanol; Heating;

DOI:10.1016/j.bmcl.2003.12.083

Reference yield:

N'-[1-(3-Cyano-phenyl)-meth-(E)-ylidene]-hydrazinecarboxylic acid tert-butyl ester (386768-80-5) → azepane-1-carboxylic acid N-(3-cyano-benzyl)-hydrazide (772332-80-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: H₂ / Pd/C / methanol

2.1: CH₂Cl₂

2.2: DIEA / CH₂Cl₂

3.1: HCl (gas); AcOH

With hydrogenchloride; hydrogen; acetic acid; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2003.12.083

Reference yield:

N'-[1-(3-Cyano-phenyl)-meth-(E)-ylidene]-hydrazinecarboxylic acid tert-butyl ester (386768-80-5) → tert-Butyl 2-(3-cyanobenzyl)-2-[(2-methyl-1-piperidinyl)carbonyl]-1-hydrazinecarboxylate (439926-82-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: H₂ / Pd/C / methanol

2.1: CH₂Cl₂

2.2: DIEA / CH₂Cl₂

With hydrogen; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2003.12.083

upstream raw materials:

t-butoxycarbonylhydrazine

3-Cyanobenzaldehyde

Downstream raw materials:

4-methyl-piperidine-1-carboxylic acid N-(3-cyano-benzyl)-hydrazide

tert-butyl 2-(3-cyanobenzyl)-2-[(4-methyl-1-piperidinyl)carbonyl]hydrazinecarboxylate

N'-(3-cyanobenzyl)-6-methoxy-N-[(4-methyl-1-piperidinyl)carbonyl]-2-naphthalenesulfonohydrazide

2-methyl-piperidine-1-carboxylic acid N-(3-cyano-benzyl)-hydrazide