[(S)-2-((1R,3aR,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-propoxy]-tert-butyl-dimethyl-silane

Base Information

• Chemical Name: [(S)-2-((1R,3aR,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-propoxy]-tert-butyl-dimethyl-silane
• CAS No.: 96845-32-8
• Molecular Formula: C₂₆H₄₄O₂Si
• Molecular Weight: 416.72

Synonyms:[(S)-2-((1R,3aR,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-propoxy]-tert-butyl-dimethyl-silane

Chemical Property of [(S)-2-((1R,3aR,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-propoxy]-tert-butyl-dimethyl-silane

Chemical Property:

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Technology Process of [(S)-2-((1R,3aR,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-propoxy]-tert-butyl-dimethyl-silane

There total 3 articles about [(S)-2-((1R,3aR,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-propoxy]-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol (64190-52-9) → [(S)-2-((1R,3aR,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-propoxy]-tert-butyl-dimethyl-silane (96845-32-8)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole

2: NaH

With 1H-imidazole; sodium hydride;

DOI:10.1016/S0040-4039(00)75805-9

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → [(S)-2-((1R,3aR,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-propoxy]-tert-butyl-dimethyl-silane (96845-32-8)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole

2: NaH

With 1H-imidazole; sodium hydride;

DOI:10.1016/S0040-4039(00)75805-9

Reference yield:

benzyl bromide (100-39-0) + (1R,3aR,4S,7aR)-1-((S)-1-((tert-butyldimethylsilyl)oxy)propan-2-yl)-7a-methyloctahydro-1H-inden-4-ol (96845-30-6) → [(S)-2-((1R,3aR,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-propoxy]-tert-butyl-dimethyl-silane (96845-32-8)

Guidance literature:

In N,N-dimethyl-formamide; at 23 ℃; for 18h;

DOI:10.1021/jo00214a046

upstream raw materials:

benzyl bromide

(1R,3aR,4S,7aR)-1-((S)-1-((tert-butyldimethylsilyl)oxy)propan-2-yl)-7a-methyloctahydro-1H-inden-4-ol

(8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol

tert-butyldimethylsilyl chloride

Downstream raw materials:

(2S,4R)-4-{(S)-1-[(R)-2-((1R,3aR,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-propyl]-3-methyl-but-3-enyloxy}-pentan-2-ol

(R)-4-{(S)-1-[(R)-2-((1R,3aR,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-propyl]-3-methyl-but-3-enyloxy}-pentan-2-one

Toluene-4-sulfonic acid (S)-2-((1R,3aR,4S,7aR)-4-benzyloxy-7a-methyl-octahydro-inden-1-yl)-propyl ester

(4S,6S)-2-[(R)-2-((1R,3aR,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-propyl]-4,6-dimethyl-[1,3]dioxane

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