tert-butyl 4-(4-((2-(2,5-difluorobenzyl)-5-oxo-5,6-dihydropyrido[2,3-d]pyridazin-4-yl)amino)-3-methoxyphenyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-((2-(2,5-difluorobenzyl)-5-oxo-5,6-dihydropyrido[2,3-d]pyridazin-4-yl)amino)-3-methoxyphenyl)piperidine-1-carboxylate
CAS No.:1390658-91-9
Molecular Formula:C₃₁H₃₃F₂N₅O₄
Molecular Weight:577.631
Hs Code.:

Synonyms:tert-butyl 4-(4-((2-(2,5-difluorobenzyl)-5-oxo-5,6-dihydropyrido[2,3-d]pyridazin-4-yl)amino)-3-methoxyphenyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-((2-(2,5-difluorobenzyl)-5-oxo-5,6-dihydropyrido[2,3-d]pyridazin-4-yl)amino)-3-methoxyphenyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(4-((2-(2,5-difluorobenzyl)-5-oxo-5,6-dihydropyrido[2,3-d]pyridazin-4-yl)amino)-3-methoxyphenyl)piperidine-1-carboxylate

There total 11 articles about tert-butyl 4-(4-((2-(2,5-difluorobenzyl)-5-oxo-5,6-dihydropyrido[2,3-d]pyridazin-4-yl)amino)-3-methoxyphenyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1390657-97-2
tert-butyl 4-(4-((2-chloro-5-oxo-5,6-dihydropyrido[2,3-d]pyridazin-4-yl)amino)-3-methoxyphenyl)piperidine-1-carboxylate

: 307496-32-8
(2,5-difluorobenzyl)zinc (II) bromide

: 1390658-91-9
tert-butyl 4-(4-((2-(2,5-difluorobenzyl)-5-oxo-5,6-dihydropyrido[2,3-d]pyridazin-4-yl)amino)-3-methoxyphenyl)piperidine-1-carboxylate

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 80 ℃; for 15h; Inert atmosphere; Sealed tube;

Reference yield:

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1390658-91-9
tert-butyl 4-(4-((2-(2,5-difluorobenzyl)-5-oxo-5,6-dihydropyrido[2,3-d]pyridazin-4-yl)amino)-3-methoxyphenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 15 h / 90 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / methanol / 8 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 18 h / 130 °C / Sealed tube

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 15 h / 80 °C / Inert atmosphere; Sealed tube

With hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water;

Reference yield:

: 686279-09-4
ethyl 4,6-dichloro-2-methylpyridine-3-carboxylate

: 1390658-91-9
tert-butyl 4-(4-((2-(2,5-difluorobenzyl)-5-oxo-5,6-dihydropyrido[2,3-d]pyridazin-4-yl)amino)-3-methoxyphenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 24 h / 85 °C

2: N-methylpiperidine-N-oxide / acetonitrile / 1 h / 20 °C / Molecular sieve

3: 1,4-dioxane / 15 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 18 h / 130 °C / Sealed tube

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 15 h / 80 °C / Inert atmosphere; Sealed tube

With N-methylpiperidine-N-oxide; N-Bromosuccinimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; dibenzoyl peroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; acetonitrile;