N-methyl-1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo-[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-phenylmethanesulfonamide

Base Information

Chemical Name:N-methyl-1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo-[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-phenylmethanesulfonamide
CAS No.:1001915-87-2
Molecular Formula:C₂₆H₂₂N₄O₃S
Molecular Weight:470.552
Hs Code.:

Synonyms:N-methyl-1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo-[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-phenylmethanesulfonamide

Suppliers and Price of N-methyl-1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo-[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-phenylmethanesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-methyl-1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo-[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-phenylmethanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-methyl-1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo-[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-phenylmethanesulfonamide

There total 3 articles about N-methyl-1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo-[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-phenylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1001915-86-1
1-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-methyl-N-phenylmethanesulfonamide

: 761446-44-0
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1001915-87-2
N-methyl-1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo-[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-phenylmethanesulfonamide

Guidance literature:: With potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In N,N-dimethyl-formamide; at 130 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm301619u

Reference yield:

: 1001915-85-0
methyl (3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]-pyridin-7-yl)[methyl(phenyl)sulfamoyl]acetate

: 1001915-87-2
N-methyl-1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo-[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-phenylmethanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / 1,4-dioxane / 1 h / 50 °C

2: potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate / N,N-dimethyl-formamide / 2 h / 130 °C / Inert atmosphere

With potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm301619u

Reference yield:

: 117765-67-0
methyl {[methyl(phenyl)amino]sulfonyl}acetate

: 1001915-87-2
N-methyl-1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo-[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-phenylmethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium t-butanolate / 1,4-dioxane / 0.25 h / 20 °C

1.2: 1 h / 90 °C / Inert atmosphere

2.1: sodium hydroxide / 1,4-dioxane / 1 h / 50 °C

3.1: potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate / N,N-dimethyl-formamide / 2 h / 130 °C / Inert atmosphere

With potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydroxide; sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm301619u