methyl (3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]-pyridin-7-yl)[methyl(phenyl)sulfamoyl]acetate

Base Information

Chemical Name:methyl (3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]-pyridin-7-yl)[methyl(phenyl)sulfamoyl]acetate
CAS No.:1001915-85-0
Molecular Formula:C₂₄H₁₉ClN₂O₅S
Molecular Weight:482.944
Hs Code.:

Synonyms:methyl (3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]-pyridin-7-yl)[methyl(phenyl)sulfamoyl]acetate

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Chemical Property of methyl (3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]-pyridin-7-yl)[methyl(phenyl)sulfamoyl]acetate

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Technology Process of methyl (3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]-pyridin-7-yl)[methyl(phenyl)sulfamoyl]acetate

There total 1 articles about methyl (3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]-pyridin-7-yl)[methyl(phenyl)sulfamoyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 917878-65-0
7-bromo-3-chloro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one

: 117765-67-0
methyl {[methyl(phenyl)amino]sulfonyl}acetate

: 1001915-85-0
methyl (3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]-pyridin-7-yl)[methyl(phenyl)sulfamoyl]acetate

Guidance literature:: methyl {[methyl(phenyl)amino]sulfonyl}acetate; With sodium t-butanolate; In 1,4-dioxane; at 20 ℃; for 0.25h;

7-bromo-3-chloro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one; With palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; at 90 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm301619u

Reference yield:

: 1001915-85-0
methyl (3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]-pyridin-7-yl)[methyl(phenyl)sulfamoyl]acetate

: 1001915-86-1
1-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-methyl-N-phenylmethanesulfonamide

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; at 50 ℃; for 1h;
DOI:10.1021/jm301619u

Reference yield:

: 1001915-85-0
methyl (3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]-pyridin-7-yl)[methyl(phenyl)sulfamoyl]acetate

: 1001915-87-2
N-methyl-1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo-[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-phenylmethanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / 1,4-dioxane / 1 h / 50 °C

2: potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate / N,N-dimethyl-formamide / 2 h / 130 °C / Inert atmosphere

With potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm301619u