1-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-methyl-N-phenylmethanesulfonamide

Base Information

Chemical Name:1-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-methyl-N-phenylmethanesulfonamide
CAS No.:1001915-86-1
Molecular Formula:C₂₂H₁₇ClN₂O₃S
Molecular Weight:424.908
Hs Code.:

Synonyms:1-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-methyl-N-phenylmethanesulfonamide

Suppliers and Price of 1-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-methyl-N-phenylmethanesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Matrix Scientific
1-(3-Chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]-pyridin-7-yl)-N-methyl-N-phenylmethanesulfonamide 97%
5g
$ 9000.00

Total 1 raw suppliers

Chemical Property of 1-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-methyl-N-phenylmethanesulfonamide

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

1-(3-Chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]-pyridin-7-yl)-N-methyl-N-phenylmethanesulfonamide 97% ^*data from reagent suppliers

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Technology Process of 1-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-methyl-N-phenylmethanesulfonamide

There total 3 articles about 1-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-methyl-N-phenylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 917878-65-0
7-bromo-3-chloro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one

: 117765-67-0
methyl {[methyl(phenyl)amino]sulfonyl}acetate

: 1001915-86-1
1-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-methyl-N-phenylmethanesulfonamide

Guidance literature:: 7-bromo-3-chloro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one; methyl {[methyl(phenyl)amino]sulfonyl}acetate; With sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate; palladium diacetate; In 1,4-dioxane; at 0 - 90 ℃; for 1.75h;

With sodium hydroxide; In 1,4-dioxane; water; at 50 ℃; for 1h;

Reference yield:

: 1001915-85-0
methyl (3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]-pyridin-7-yl)[methyl(phenyl)sulfamoyl]acetate

: 1001915-86-1
1-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-methyl-N-phenylmethanesulfonamide

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; at 50 ℃; for 1h;
DOI:10.1021/jm301619u

Reference yield:

: 117765-67-0
methyl {[methyl(phenyl)amino]sulfonyl}acetate

: 1001915-86-1
1-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-methyl-N-phenylmethanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium t-butanolate / 1,4-dioxane / 0.25 h / 20 °C

1.2: 1 h / 90 °C / Inert atmosphere

2.1: sodium hydroxide / 1,4-dioxane / 1 h / 50 °C

With sodium hydroxide; sodium t-butanolate; In 1,4-dioxane;
DOI:10.1021/jm301619u