{4-[(4-bromophenylamino)methyl]tetrahydropyran-4-yl}carbamic acid tert-butyl ester

Base Information

Chemical Name:{4-[(4-bromophenylamino)methyl]tetrahydropyran-4-yl}carbamic acid tert-butyl ester
CAS No.:1287205-92-8
Molecular Formula:C₁₇H₂₅BrN₂O₃
Molecular Weight:385.301
Hs Code.:

Synonyms:{4-[(4-bromophenylamino)methyl]tetrahydropyran-4-yl}carbamic acid tert-butyl ester

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Chemical Property of {4-[(4-bromophenylamino)methyl]tetrahydropyran-4-yl}carbamic acid tert-butyl ester

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Technology Process of {4-[(4-bromophenylamino)methyl]tetrahydropyran-4-yl}carbamic acid tert-butyl ester

There total 3 articles about {4-[(4-bromophenylamino)methyl]tetrahydropyran-4-yl}carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 885498-49-7
tert-butyl (4-formyltetrahydro-2H-pyran-4-yl)carbamate

: 106-40-1
4-bromo-aniline

: 1287205-92-8
{4-[(4-bromophenylamino)methyl]tetrahydropyran-4-yl}carbamic acid tert-butyl ester

Guidance literature:: tert-butyl (4-formyltetrahydro-2H-pyran-4-yl)carbamate; 4-bromo-aniline; With acetic acid; In ethyl acetate; at 20 ℃; for 2h; Inert atmosphere;

With sodium cyanoborohydride; In ethyl acetate;

With water; In ethyl acetate;

Reference yield:

: 172843-97-9
4-(Boc-amino)tetrahydropyran-4-carboxylic acid

: 1287205-92-8
{4-[(4-bromophenylamino)methyl]tetrahydropyran-4-yl}carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.42 h / 65 °C / Inert atmosphere

2.2: 0.33 h / 65 °C

3.1: acetic acid / ethyl acetate / 2 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; oxalyl dichloride; acetic acid; dimethyl sulfoxide; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; ethyl acetate;

Reference yield:

: 1029716-09-3
tert-butyl (4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)carbamate

: 1287205-92-8
{4-[(4-bromophenylamino)methyl]tetrahydropyran-4-yl}carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.42 h / 65 °C / Inert atmosphere

1.2: 0.33 h / 65 °C

2.1: acetic acid / ethyl acetate / 2 h / 20 °C / Inert atmosphere

With oxalyl dichloride; acetic acid; dimethyl sulfoxide; In dichloromethane; ethyl acetate;