endo-1-hydroxy-exo-1-methyl-2,2-diphenyl-1,1a,2,2a-tetrahydro-7H-cyclobutindene

• Chemical Name: endo-1-hydroxy-exo-1-methyl-2,2-diphenyl-1,1a,2,2a-tetrahydro-7H-cyclobutindene
• Molecular Formula: C₂₄H₂₂O
• Molecular Weight: 326.438
• Mol file: 74401-24-4.mol

Synonyms:endo-1-hydroxy-exo-1-methyl-2,2-diphenyl-1,1a,2,2a-tetrahydro-7H-cyclobutindene

Chemical Property of endo-1-hydroxy-exo-1-methyl-2,2-diphenyl-1,1a,2,2a-tetrahydro-7H-cyclobut

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of endo-1-hydroxy-exo-1-methyl-2,2-diphenyl-1,1a,2,2a-tetrahydro-7H-cyclobut

There total 1 articles about endo-1-hydroxy-exo-1-methyl-2,2-diphenyl-1,1a,2,2a-tetrahydro-7H-cyclobutindene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl magnesium iodide (917-64-6) + 2,2-diphenyl-1,1a,2,2a-tetrahydro-7H-cyclobutinden-1-one (3582-45-4,100410-70-6) → endo-1-hydroxy-exo-1-methyl-2,2-diphenyl-1,1a,2,2a-tetrahydro-7H-cyclobutindene (74401-24-4)

Guidance literature:

In diethyl ether; for 3h;

DOI:10.1021/ja00536a025

Reference yield:

endo-1-hydroxy-exo-1-methyl-2,2-diphenyl-1,1a,2,2a-tetrahydro-7H-cyclobutindene (74401-24-4) → 1,1-diphenylacetone (781-35-1) + 1-indene (95-13-6)

Guidance literature:

With DCNB; Irradiation;

DOI:10.1021/ja00536a025

Reference yield:

endo-1-hydroxy-exo-1-methyl-2,2-diphenyl-1,1a,2,2a-tetrahydro-7H-cyclobutindene (74401-24-4) → endo-2-phenyl-1,1a,2,2a-tetrahydro-7H-cyclobutindene (72261-57-5)

Guidance literature:

Multi-step reaction with 6 steps

1: DCNB / Irradiation

2: 78 percent / benzene / 16 h / Irradiation

3: 92 percent / lithium aluminium hydride

4: sodium hydroxide

5: 44 percent / sodium hydroxide / H₂O / 200 °C

6: 80 percent / hydrogen / 5percent palladium-carbon

With sodium hydroxide; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In water; benzene;

DOI:10.1021/ja00536a025

upstream raw materials:

methyl magnesium iodide

2,2-diphenyl-1,1a,2,2a-tetrahydro-7H-cyclobutinden-1-one

Downstream raw materials:

1,1-diphenylacetone

1-indene

2-phenyl-1a,2a-dihydro-7H-cyclobutindene

endo-2-phenyl-1,1a,2,2a-tetrahydro-7H-cyclobutindene