(R)-α-(formylmethyl)phenylacetate de methyle

Base Information

Chemical Name:(R)-α-(formylmethyl)phenylacetate de methyle
CAS No.:113985-92-5
Molecular Formula:C₁₁H₁₂O₃
Molecular Weight:192.214
Hs Code.:

Synonyms:(R)-α-(formylmethyl)phenylacetate de methyle

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Chemical Property of (R)-α-(formylmethyl)phenylacetate de methyle

Chemical Property:

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Technology Process of (R)-α-(formylmethyl)phenylacetate de methyle

There total 5 articles about (R)-α-(formylmethyl)phenylacetate de methyle which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 725257-89-6
(2S,4S)-2-[(4S)-4-isobutyl-2-oxo-1,3-oxazolidin-3-yl]-4-phenyl-3,4-dihydro-2H-pyran-6-carboxylic acid methyl ester

: 113985-92-5
(R)-α-(formylmethyl)phenylacetate de methyle

Guidance literature:: (2S,4S)-2-[(4S)-4-isobutyl-2-oxo-1,3-oxazolidin-3-yl]-4-phenyl-3,4-dihydro-2H-pyran-6-carboxylic acid methyl ester; With sodium hydrogencarbonate; ozone; In methanol; dichloromethane; at -78 ℃;

With acetic anhydride; triethylamine; In methanol; dichloromethane; at 20 ℃; for 16h;

With sulfuric acid;
DOI:10.1021/jo040102y

Reference yield:

: 107969-78-8
methyl benzylidenepyruvate

: 113985-92-5
(R)-α-(formylmethyl)phenylacetate de methyle

Guidance literature:: Multi-step reaction with 2 steps

1.1: 92 percent / Eu(fod)3 / cyclohexane / 144 h / Heating

2.1: ozone; NaHCO₃ / methanol; CH₂Cl₂ / -78 °C

2.2: triethylamine; acetic anhydride / CH₂Cl₂; methanol / 16 h / 20 °C

2.3: 61 percent / H₂SO₄

With sodium hydrogencarbonate; ozone; Eu(fod)3; In methanol; dichloromethane; cyclohexane;
DOI:10.1021/jo040102y

Reference yield:

: 1914-59-6
(E)-2-oxo-4-phenyl-3-butenoic acid

: 113985-92-5
(R)-α-(formylmethyl)phenylacetate de methyle

Guidance literature:: Multi-step reaction with 3 steps

1: HCl / Heating

2: 60 percent / Eu(fod)3 / hexane / 144 h / 20 °C

3: 1.) O₃, NaHCO₃, 2.) Et₃N, Ac₂O / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, -78 deg C to room temp., 12 h

With hydrogenchloride; acetic anhydride; sodium hydrogencarbonate; ozone; triethylamine; Eu(fod)3; In hexane;
DOI:10.1016/S0040-4020(01)85370-9