5-[6-(4-bromo-phenyl)-5,7-dioxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[4,3-d]pyrimidin-1-yl]-2-fluoro-benzonitrile

Base Information

Chemical Name:5-[6-(4-bromo-phenyl)-5,7-dioxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[4,3-d]pyrimidin-1-yl]-2-fluoro-benzonitrile
CAS No.:913176-73-5
Molecular Formula:C₁₉H₈BrF₄N₅O₂
Molecular Weight:494.202
Hs Code.:

5-[6-(4-bromo-phenyl)-5,7-dioxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[4,3-<i>d</i>]pyrimidin-1-yl]-2-fluoro-benzonitrile

Synonyms:5-[6-(4-bromo-phenyl)-5,7-dioxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[4,3-d]pyrimidin-1-yl]-2-fluoro-benzonitrile

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Chemical Property of 5-[6-(4-bromo-phenyl)-5,7-dioxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[4,3-d]pyrimidin-1-yl]-2-fluoro-benzonitrile

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Technology Process of 5-[6-(4-bromo-phenyl)-5,7-dioxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[4,3-d]pyrimidin-1-yl]-2-fluoro-benzonitrile

There total 5 articles about 5-[6-(4-bromo-phenyl)-5,7-dioxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[4,3-d]pyrimidin-1-yl]-2-fluoro-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 913176-67-7
4-amino-2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (4-bromo-phenyl)-amide

: 75-44-5
phosgene

: 913176-73-5
5-[6-(4-bromo-phenyl)-5,7-dioxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[4,3-d]pyrimidin-1-yl]-2-fluoro-benzonitrile

Guidance literature:: In toluene; at 110 ℃;
DOI:10.1016/j.bmcl.2006.07.002

Reference yield:

: 209960-58-7
1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic Acid

: 913176-73-5
5-[6-(4-bromo-phenyl)-5,7-dioxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[4,3-d]pyrimidin-1-yl]-2-fluoro-benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / ammonium nitrate; trifluoroacetic anhydride / trifluoroacetic acid

2: (COCl)2 / CH₂Cl₂

3: DMAP / CH₂Cl₂

4: 70 percent / KBH₄; CuCl / ethanol

5: 85 percent / toluene / 110 °C

With dmap; ammonium nitrate; potassium borohydride; oxalyl dichloride; trifluoroacetic anhydride; copper(l) chloride; In ethanol; dichloromethane; toluene; trifluoroacetic acid;
DOI:10.1016/j.bmcl.2006.07.002

Reference yield:

: 280119-96-2
[1-(3-cyano-4-fluorophenyl)]-3-trifluoromethyl-4-nitro-pyrazole-5-carboxylic acid

: 913176-73-5
5-[6-(4-bromo-phenyl)-5,7-dioxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[4,3-d]pyrimidin-1-yl]-2-fluoro-benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: (COCl)2 / CH₂Cl₂

2: DMAP / CH₂Cl₂

3: 70 percent / KBH₄; CuCl / ethanol

4: 85 percent / toluene / 110 °C

With dmap; potassium borohydride; oxalyl dichloride; copper(l) chloride; In ethanol; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2006.07.002