methyclothiazide

Base Information

• Chemical Name: methyclothiazide
• CAS No.: 96783-14-1
• Molecular Formula: C₉H₁₁Cl₂N₃O₄S₂
• Molecular Weight: 360.242
• Mol file: 96783-14-1.mol

Synonyms:

Chemical Property of methyclothiazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyclothiazide

There total 5 articles about methyclothiazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloraminophenamide (121-30-2) → Methyclothiazid (135-07-9,96783-14-1,96783-15-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1 h / 180 °C

2: NaH / dimethylformamide / 1 h / 70 °C

3: aq. NaOH / Heating

4: H₂O

With sodium hydroxide; sodium hydride; In water; N,N-dimethyl-formamide;

DOI:10.1021/ja01490a028

Reference yield:

6-chloro-3,4-dihydro-3-oxo-2H-1,2,4-benzothiadiazine-7-sulfonamide,1,1-dioxide (89813-56-9) → Methyclothiazid (135-07-9,96783-14-1,96783-15-2)

Guidance literature:

Multi-step reaction with 3 steps

1: NaH / dimethylformamide / 1 h / 70 °C

2: aq. NaOH / Heating

3: H₂O

With sodium hydroxide; sodium hydride; In water; N,N-dimethyl-formamide;

DOI:10.1021/ja01490a028

Reference yield:

6-chloro-2-methyl-1,1,3-trioxo-1,2,3,4-tetrahydro-1λ6-benzo[1,2,4]thiadiazine-7-sulfonic acid amide (89813-57-0) → Methyclothiazid (135-07-9,96783-14-1,96783-15-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / Heating

2: H₂O

With sodium hydroxide; In water;

DOI:10.1021/ja01490a028

upstream raw materials:

2-chloroethanal

4-amino-2-chloro-5-(methylsulfamyl)benzenesulfonamide

chloraminophenamide

6-chloro-3,4-dihydro-3-oxo-2H-1,2,4-benzothiadiazine-7-sulfonamide,1,1-dioxide

Downstream raw materials:

4-amino-2-chloro-5-(methylsulfamyl)benzenesulfonamide