(S)-1-(5-chloro-2-nitrophenyl)-1-trifluoromethyl-3-cyclopropyl-2-propyn-1-ol

Base Information Edit

Chemical Name:(S)-1-(5-chloro-2-nitrophenyl)-1-trifluoromethyl-3-cyclopropyl-2-propyn-1-ol
CAS No.:1352784-90-7
Molecular Formula:C₁₃H₉ClF₃NO₃
Molecular Weight:319.668
Hs Code.:
Mol file:1352784-90-7.mol

Synonyms:(S)-1-(5-chloro-2-nitrophenyl)-1-trifluoromethyl-3-cyclopropyl-2-propyn-1-ol

Suppliers and Price of (S)-1-(5-chloro-2-nitrophenyl)-1-trifluoromethyl-3-cyclopropyl-2-propyn-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-(5-chloro-2-nitrophenyl)-1-trifluoromethyl-3-cyclopropyl-2-propyn-1-ol Edit

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Technology Process of (S)-1-(5-chloro-2-nitrophenyl)-1-trifluoromethyl-3-cyclopropyl-2-propyn-1-ol

There total 8 articles about (S)-1-(5-chloro-2-nitrophenyl)-1-trifluoromethyl-3-cyclopropyl-2-propyn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1352784-89-4
1-(5-chloro-2-nitrophenyl)-3-cyclopropylprop-2-yn-1-one

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 1352784-90-7
(S)-1-(5-chloro-2-nitrophenyl)-1-trifluoromethyl-3-cyclopropyl-2-propyn-1-ol

Guidance literature:: 1-(5-chloro-2-nitrophenyl)-3-cyclopropylprop-2-yn-1-one; (trifluoromethyl)trimethylsilane; With C₄₇H₄₁F₁₂N₂O₂⁽¹⁺⁾*Br^(1-); tetramethylammonium fluoride; In dichloromethane; toluene; at -90 ℃; for 4h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h; enantioselective reaction;

Reference yield:

: 216006-64-3
cyclopropylacetylene magnesium chloride

: 1-(5-chloro-2-nitrophenyl)-2,2,2-trifluoroethanone

: 1352784-90-7
(S)-1-(5-chloro-2-nitrophenyl)-1-trifluoromethyl-3-cyclopropyl-2-propyn-1-ol

Guidance literature:: cyclopropylacetylene magnesium chloride; With zinc trifluoromethanesulfonate; (1R,2S)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol; triethylamine; In 2-methyltetrahydrofuran; toluene; at 18 ℃; for 1h;

1-(5-chloro-2-nitrophenyl)-2,2,2-trifluoroethanone; In 2-methyltetrahydrofuran; toluene; at -10 - -6 ℃; for 22h; Temperature;