3-(2-(diethylamino)-1-hydroxyethyl)-5-(5-methylpyridin-2-yl)-N-((R)-1-(6-methylpyridin-3-yl)ethyl)benzamide

Base Information

Chemical Name:3-(2-(diethylamino)-1-hydroxyethyl)-5-(5-methylpyridin-2-yl)-N-((R)-1-(6-methylpyridin-3-yl)ethyl)benzamide
CAS No.:1186517-97-4
Molecular Formula:C₂₇H₃₄N₄O₂
Molecular Weight:446.593
Hs Code.:

Synonyms:3-(2-(diethylamino)-1-hydroxyethyl)-5-(5-methylpyridin-2-yl)-N-((R)-1-(6-methylpyridin-3-yl)ethyl)benzamide

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Chemical Property of 3-(2-(diethylamino)-1-hydroxyethyl)-5-(5-methylpyridin-2-yl)-N-((R)-1-(6-methylpyridin-3-yl)ethyl)benzamide

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Technology Process of 3-(2-(diethylamino)-1-hydroxyethyl)-5-(5-methylpyridin-2-yl)-N-((R)-1-(6-methylpyridin-3-yl)ethyl)benzamide

There total 8 articles about 3-(2-(diethylamino)-1-hydroxyethyl)-5-(5-methylpyridin-2-yl)-N-((R)-1-(6-methylpyridin-3-yl)ethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-1-(6-methylpyridin-3-yl)ethanamine dihydrochloride

: 1186520-10-4
3-(2-(diethylamino)-2-hydroxyethyl)-5-(5-methylpyridin-2-yl)benzoic acid

: 1186517-97-4
3-(2-(diethylamino)-1-hydroxyethyl)-5-(5-methylpyridin-2-yl)-N-((R)-1-(6-methylpyridin-3-yl)ethyl)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 25 ℃; for 16h;

Reference yield:

: 307353-32-8
3-bromo-5-hydroxymethylbenzoic acid methyl ester

: 1186517-97-4
3-(2-(diethylamino)-1-hydroxyethyl)-5-(5-methylpyridin-2-yl)-N-((R)-1-(6-methylpyridin-3-yl)ethyl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: manganese(IV) oxide / dichloromethane / 20 °C

2.1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere; warming

2.2: 0.33 h / 0 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

4.1: ethanol / 50 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 2 h / 120 °C / Inert atmosphere; Microwave irradiation

6.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 50 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 25 °C

With manganese(IV) oxide; n-butyllithium; water; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; HATU; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1186519-96-9
methyl 3-bromo-5-vinylbenzoate

: 1186517-97-4
3-(2-(diethylamino)-1-hydroxyethyl)-5-(5-methylpyridin-2-yl)-N-((R)-1-(6-methylpyridin-3-yl)ethyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

2: ethanol / 50 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 2 h / 120 °C / Inert atmosphere; Microwave irradiation

4: water; lithium hydroxide / tetrahydrofuran / 3 h / 50 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 25 °C

With water; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; HATU; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;