3-(2-(diethylamino)-2-hydroxyethyl)-5-(5-methylpyridin-2-yl)benzoic acid

Base Information

Chemical Name:3-(2-(diethylamino)-2-hydroxyethyl)-5-(5-methylpyridin-2-yl)benzoic acid
CAS No.:1186520-10-4
Molecular Formula:C₁₉H₂₄N₂O₃
Molecular Weight:328.411
Hs Code.:

Synonyms:3-(2-(diethylamino)-2-hydroxyethyl)-5-(5-methylpyridin-2-yl)benzoic acid

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Chemical Property of 3-(2-(diethylamino)-2-hydroxyethyl)-5-(5-methylpyridin-2-yl)benzoic acid

Chemical Property:

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Technology Process of 3-(2-(diethylamino)-2-hydroxyethyl)-5-(5-methylpyridin-2-yl)benzoic acid

There total 7 articles about 3-(2-(diethylamino)-2-hydroxyethyl)-5-(5-methylpyridin-2-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1186519-36-7
methyl 3-(2-(diethylamino)-2-hydroxyethyl)-5-(5-methylpyridin-2-yl)benzoate

: 1186520-10-4
3-(2-(diethylamino)-2-hydroxyethyl)-5-(5-methylpyridin-2-yl)benzoic acid

Guidance literature:: methyl 3-(2-(diethylamino)-2-hydroxyethyl)-5-(5-methylpyridin-2-yl)benzoate; With water; lithium hydroxide; In tetrahydrofuran; at 50 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 307353-32-8
3-bromo-5-hydroxymethylbenzoic acid methyl ester

: 1186520-10-4
3-(2-(diethylamino)-2-hydroxyethyl)-5-(5-methylpyridin-2-yl)benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: manganese(IV) oxide / dichloromethane / 20 °C

2.1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere; warming

2.2: 0.33 h / 0 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

4.1: ethanol / 50 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 2 h / 120 °C / Inert atmosphere; Microwave irradiation

6.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 50 °C

With manganese(IV) oxide; n-butyllithium; water; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; toluene;

Reference yield:

: 1186519-96-9
methyl 3-bromo-5-vinylbenzoate

: 1186520-10-4
3-(2-(diethylamino)-2-hydroxyethyl)-5-(5-methylpyridin-2-yl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

2: ethanol / 50 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 2 h / 120 °C / Inert atmosphere; Microwave irradiation

4: water; lithium hydroxide / tetrahydrofuran / 3 h / 50 °C

With water; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; toluene;