2-(3-(((3-((2-methoxyethyl)amino)-3-oxopropyl)(methyl)amino)methyl)benzamido)-5-(piperidin-1-yl)-N-(1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)benzamide

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Chemical Name:2-(3-(((3-((2-methoxyethyl)amino)-3-oxopropyl)(methyl)amino)methyl)benzamido)-5-(piperidin-1-yl)-N-(1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)benzamide
CAS No.:1354721-77-9
Molecular Formula:C₃₇H₄₂F₃N₇O₄
Molecular Weight:705.78
Hs Code.:

2-(3-(((3-((2-methoxyethyl)amino)-3-oxopropyl)(methyl)amino)methyl)benzamido)-5-(piperidin-1-yl)-N-(1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)benzamide

Synonyms:2-(3-(((3-((2-methoxyethyl)amino)-3-oxopropyl)(methyl)amino)methyl)benzamido)-5-(piperidin-1-yl)-N-(1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)benzamide

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Chemical Property of 2-(3-(((3-((2-methoxyethyl)amino)-3-oxopropyl)(methyl)amino)methyl)benzamido)-5-(piperidin-1-yl)-N-(1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)benzamide

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Technology Process of 2-(3-(((3-((2-methoxyethyl)amino)-3-oxopropyl)(methyl)amino)methyl)benzamido)-5-(piperidin-1-yl)-N-(1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)benzamide

There total 6 articles about 2-(3-(((3-((2-methoxyethyl)amino)-3-oxopropyl)(methyl)amino)methyl)benzamido)-5-(piperidin-1-yl)-N-(1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1051858-01-5
N-(2-methoxyethyl)-3-(methylamino)propanamide

: 1354722-28-3
2-(3-(bromomethyl)benzamido)-5-(piperidin-1-yl)-N-(1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)benzamide

: 1354721-77-9
2-(3-(((3-((2-methoxyethyl)amino)-3-oxopropyl)(methyl)amino)methyl)benzamido)-5-(piperidin-1-yl)-N-(1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)benzamide

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 70 ℃; for 1.5h;

Reference yield:

: 401-81-0
m-trifluoromethylphenyl iodide

: 1354721-77-9
2-(3-(((3-((2-methoxyethyl)amino)-3-oxopropyl)(methyl)amino)methyl)benzamido)-5-(piperidin-1-yl)-N-(1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate; L-proline; copper(l) iodide / dimethyl sulfoxide / 85 °C

2: hydrogen / palladium on activated charcoal / methanol / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 50 °C

4: hydrogen / palladium on activated charcoal / ethyl acetate; methanol / 1 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2.5 h / 0 - 20 °C

6: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 1.5 h / 70 °C

With copper(l) iodide; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; L-proline; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 66000-41-7
1-(3-(trifluoromethyl)phenyl)-3-amino-1H-pyrazole

: 1354721-77-9
2-(3-(((3-((2-methoxyethyl)amino)-3-oxopropyl)(methyl)amino)methyl)benzamido)-5-(piperidin-1-yl)-N-(1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 50 °C

2: hydrogen / palladium on activated charcoal / ethyl acetate; methanol / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2.5 h / 0 - 20 °C

4: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 1.5 h / 70 °C

With hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;