tert-butyl 5-(7-carbamothioyl-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

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Chemical Name:tert-butyl 5-(7-carbamothioyl-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate
CAS No.:1373278-20-6
Molecular Formula:C₂₄H₂₆FN₃O₃S
Molecular Weight:455.553
Hs Code.:

Synonyms:tert-butyl 5-(7-carbamothioyl-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

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Chemical Property of tert-butyl 5-(7-carbamothioyl-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

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Technology Process of tert-butyl 5-(7-carbamothioyl-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

There total 7 articles about tert-butyl 5-(7-carbamothioyl-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.2%

: 1373278-18-2
tert-butyl 5-(7-carbamoyl-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

: 1373278-20-6
tert-butyl 5-(7-carbamothioyl-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Guidance literature:: With Lawessons reagent; In toluene; at 110 ℃; for 1h;

Reference yield:

: 1373278-11-5
2-(5-tert-butoxy-5-oxopentyl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylic acid

: 1373278-20-6
tert-butyl 5-(7-carbamothioyl-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; ammonium chloride / dichloromethane / 20 h / 20 °C

2: Lawessons reagent / toluene / 1 h / 110 °C

With Lawessons reagent; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;

Reference yield:

: 1195-45-5
para-fluorophenyl isocyanate

: 1373278-20-6
tert-butyl 5-(7-carbamothioyl-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / 1,4-dioxane / 16 h / 80 °C

2.1: trichlorophosphate; N,N-dimethyl-aniline / 36 h / 110 °C / Inert atmosphere

3.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 3.5 h / 0 - 20 °C

3.2: 16 h / 60 °C

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 0.75 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; ammonium chloride / dichloromethane / 20 h / 20 °C

6.1: Lawessons reagent / toluene / 1 h / 110 °C

With Lawessons reagent; lithium hydroxide monohydrate; water; ammonium chloride; benzotriazol-1-ol; N,N-dimethyl-aniline; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; 9-bora-bicyclo[3.3.1]nonane; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;