Technology Process of rac-6-(2-fluorophenyl)-8-iodo-4-methoxy-1-methyl-4H-<1,2,4>triazolo<4,3-a><1,4>benzodiazepine
There total 8 articles about rac-6-(2-fluorophenyl)-8-iodo-4-methoxy-1-methyl-4H-<1,2,4>triazolo<4,3-a><1,4>benzodiazepine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
thionyl chloride; triethylamine;
In
methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: liquid ammonia / CH2Cl2 / 16 h / Heating
2: HOAc / ethanol / 0.5 h / Heating
3: 80 percent / P2S5, NaHCO3 / bis-(2-methoxy-ethyl) ether / 3 h / 80 - 85 °C
4: 83 percent / hydrazine / propan-2-ol; tetrahydrofuran / 0.25 h / Ambient temperature
5: 92 percent / silica gel / toluene / 3 h / Heating
6: 1.) t-BuOK, triethyl phosphite, 2.) O2 / 1.) THF, t-BuOH, DMF, from -20 to -10 deg C, 1 h
7: SOCl2 / CH2Cl2 / 2 h / Ambient temperature
8: Et3N / 0.08 h / Heating
With
thionyl chloride; tetraphosphorus decasulfide; potassium tert-butylate; ammonia; oxygen; silica gel; sodium hydrogencarbonate; acetic acid; triethylamine; hydrazine; triethyl phosphite;
In
tetrahydrofuran; ethanol; dichloromethane; diethylene glycol dimethyl ether; isopropyl alcohol; toluene;
DOI:10.1021/jm00107a048
- Guidance literature:
-
Multi-step reaction with 10 steps
1: iodine monochloride / CH2Cl2 / 5 h / -60 °C
2: 10percent aq. Na2CO3 / CH2Cl2 / 0.5 h / 0 °C
3: liquid ammonia / CH2Cl2 / 16 h / Heating
4: HOAc / ethanol / 0.5 h / Heating
5: 80 percent / P2S5, NaHCO3 / bis-(2-methoxy-ethyl) ether / 3 h / 80 - 85 °C
6: 83 percent / hydrazine / propan-2-ol; tetrahydrofuran / 0.25 h / Ambient temperature
7: 92 percent / silica gel / toluene / 3 h / Heating
8: 1.) t-BuOK, triethyl phosphite, 2.) O2 / 1.) THF, t-BuOH, DMF, from -20 to -10 deg C, 1 h
9: SOCl2 / CH2Cl2 / 2 h / Ambient temperature
10: Et3N / 0.08 h / Heating
With
thionyl chloride; tetraphosphorus decasulfide; potassium tert-butylate; ammonia; oxygen; silica gel; Iodine monochloride; sodium hydrogencarbonate; sodium carbonate; acetic acid; triethylamine; hydrazine; triethyl phosphite;
In
tetrahydrofuran; ethanol; dichloromethane; diethylene glycol dimethyl ether; isopropyl alcohol; toluene;
DOI:10.1021/jm00107a048
