101810-77-9

Upstream product

• 101810-75-7 6-(bromomethyl)-2,4-diamino-5-methylpyrido<2,3-d>pyrimidine hydrobromide 
• 101810-76-8 N-<4-(methylamino)benzoyl>-L-glutamic acid dimethyl ester 
• 23150-65-4 L-glutamic dimethyl ester hydrochloride 
• 66891-86-9 benzyl (4-(chlorocarbonyl)phenyl)(methyl)carbamate 
• 101810-82-6 N-<4-<<(benzyloxy)carbonyl>methylamino>benzoyl>-L-glutamic acid dimethyl ester 

Downstream Products

• 101810-79-1 5-methyl-5-deazamethotrexate 
• 101810-81-5 5,10-dimethyl-5-deazafolic acid 

Relevant academic research and scientific papers

5-methyl-5-deaza analogues of methotrexate and N10 -ethylaminopterin

It is disclosed that 5-methyl-5-deazamethotrexate and 5-methyl-5-deaza-10-ethylaminopterin are more than 10 times as potent as 5-deazamethotrexate in the L1210 cell growth inhibition test.

Syntheses and Antifolate Activity of 5-Methyl-5-deaza Analogues of Aminopterin, Methotrexate, Folic Acid, and N10-Methylfolic Acid

Evidence indicating that modifications at the 5- and 10-positions of classical folic acid antimetabolites lead to compounds with favorable differential membrane transport in tumor vs. normal proliferative tissue prompted an investigation of 5-alkyl-5-deaz