O-tert-Butyl-L-threonine Methyl Ester p-Toluenesulfonate

Base Information

• Chemical Name: O-tert-Butyl-L-threonine Methyl Ester p-Toluenesulfonate
• CAS No.: 132776-34-2
• Molecular Formula: C₇H₈O₃S*C₉H₁₉NO₃
• Molecular Weight: 361.459
• Mol file: 132776-34-2.mol

Synonyms:O-tert-Butyl-L-threonine Methyl Ester p-Toluenesulfonate

Chemical Property of O-tert-Butyl-L-threonine Methyl Ester p-Toluenesulfonate

Chemical Property:

Purity/Quality:

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Technology Process of O-tert-Butyl-L-threonine Methyl Ester p-Toluenesulfonate

There total 1 articles about O-tert-Butyl-L-threonine Methyl Ester p-Toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

L-threonine methyl ester hydrochloride (39994-75-7) + toluene-4-sulfonic acid (104-15-4) + isobutene (115-11-7,15220-85-6) → O-tert-Butyl-L-threonine Methyl Ester p-Toluenesulfonate (132776-34-2)

Guidance literature:

In dichloromethane;

DOI:10.1021/jo00010a050

Reference yield:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + O-tert-Butyl-L-threonine Methyl Ester p-Toluenesulfonate (132776-34-2) → Fmoc-Thr(tBu)-OH (71989-35-0,138797-71-4)

Guidance literature:

With sodium hydroxide; Yield given. Multistep reaction; 1.) H₂O, 0 deg C, 2 h; 2.) p-dioxane, 0 deg C to r.t., 24 h;

DOI:10.1021/jo00010a050

upstream raw materials:

L-threonine methyl ester hydrochloride

toluene-4-sulfonic acid

isobutene

Downstream raw materials:

Fmoc-Thr(tBu)-OH

Refernces