(S)-2-[(S)-4-((S)-4-{4-[(2-Amino-4-hydroxy-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-pentanedioic acid

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Chemical Name:(S)-2-[(S)-4-((S)-4-{4-[(2-Amino-4-hydroxy-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-pentanedioic acid
CAS No.:121175-95-9
Molecular Formula:C₃₁H₃₂F₃N₉O₁₃
Molecular Weight:795.643
Hs Code.:

(S)-2-[(S)-4-((S)-4-{4-[(2-Amino-4-hydroxy-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-pentanedioic acid

Synonyms:(S)-2-[(S)-4-((S)-4-{4-[(2-Amino-4-hydroxy-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-pentanedioic acid

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Chemical Property of (S)-2-[(S)-4-((S)-4-{4-[(2-Amino-4-hydroxy-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-pentanedioic acid

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Technology Process of (S)-2-[(S)-4-((S)-4-{4-[(2-Amino-4-hydroxy-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-pentanedioic acid

There total 4 articles about (S)-2-[(S)-4-((S)-4-{4-[(2-Amino-4-hydroxy-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-pentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63948-16-3
α-tert-butyl N¹⁰-(trifluoroacetyl)pteroyltriglutamate

: 121175-95-9
(S)-2-[(S)-4-((S)-4-{4-[(2-Amino-4-hydroxy-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-pentanedioic acid

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; at 25 ℃; for 18h; Yield given;
DOI:10.1021/jm00164a038

Reference yield:

: 45120-30-7
L-glutamic acid α-tert-butyl ester

: 121175-95-9
(S)-2-[(S)-4-((S)-4-{4-[(2-Amino-4-hydroxy-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-pentanedioic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / 10percent Na₂CO₃ / dioxane / 20 h / 24 °C

2: dicyclohexylcarbodiimide / CH₂Cl₂ / 0.25 h

3: KH polyamide resin, 4-(dimethylamino)pyridine, N-methylmorpholine, piperidine, 1percent TFA

4: 0.1N HCl / tetrahydrofuran / 18 h / 25 °C

With piperidine; 4-methyl-morpholine; hydrogenchloride; dmap; KH polyamide resin; sodium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jm00164a038

Reference yield:

: 84793-07-7
Fmoc-Glu-OtBu

: 121175-95-9
(S)-2-[(S)-4-((S)-4-{4-[(2-Amino-4-hydroxy-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-pentanedioic acid

Guidance literature:: Multi-step reaction with 3 steps

1: dicyclohexylcarbodiimide / CH₂Cl₂ / 0.25 h

2: KH polyamide resin, 4-(dimethylamino)pyridine, N-methylmorpholine, piperidine, 1percent TFA

3: 0.1N HCl / tetrahydrofuran / 18 h / 25 °C

With piperidine; 4-methyl-morpholine; hydrogenchloride; dmap; KH polyamide resin; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00164a038