1-(2-{4-[2-(1,1-dioxo-2,3-1H-1λ⁶-benzo[b]thiophen-5-yl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine

Base Information

• Chemical Name: 1-(2-{4-[2-(1,1-dioxo-2,3-1H-1λ⁶-benzo[b]thiophen-5-yl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine
• CAS No.: 648904-94-3
• Molecular Formula: C₃₂H₃₃NO₅S
• Molecular Weight: 543.684

Synonyms:1-(2-{4-[2-(1,1-dioxo-2,3-1H-1λ⁶-benzo[b]thiophen-5-yl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine

Chemical Property of 1-(2-{4-[2-(1,1-dioxo-2,3-1H-1λ⁶-benzo[b]thiophen-5-yl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine

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Technology Process of 1-(2-{4-[2-(1,1-dioxo-2,3-1H-1λ⁶-benzo[b]thiophen-5-yl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine

There total 1 articles about 1-(2-{4-[2-(1,1-dioxo-2,3-1H-1λ⁶-benzo[b]thiophen-5-yl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

trifluoromethanesulfonic acid 6-methoxy-1-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalen-2-yl ester (648904-46-5) + 2-(1,1-dioxo-2,3-dihydro-1H-benzo[b]thiophen-5-yl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (648904-93-2) → 1-(2-{4-[2-(1,1-dioxo-2,3-1H-1λ6-benzo[b]thiophen-5-yl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine (648904-94-3)

Guidance literature:

With cesium fluoride; palladium diacetate; tricyclohexylphosphine; In acetonitrile; at 20 - 90 ℃; for 6h;

Reference yield:

1-(2-{4-[2-(1,1-dioxo-2,3-1H-1λ6-benzo[b]thiophen-5-yl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine (648904-94-3) → 6-(1,1-dioxo-2,3-dihydro-1H-1λ6-benzo[b]thiophen-5-yl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol (648904-96-5)

Guidance literature:

1-(2-{4-[2-(1,1-dioxo-2,3-1H-1λ⁶-benzo[b]thiophen-5-yl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine; With hydrogenchloride; In diethyl ether; dichloromethane; at -78 ℃; for 0.166667h;

With boron tribromide; In dichloromethane; at 0 ℃; for 1h;

With water; In dichloromethane;

upstream raw materials:

trifluoromethanesulfonic acid 6-methoxy-1-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalen-2-yl ester

2-(1,1-dioxo-2,3-dihydro-1H-benzo[b]thiophen-5-yl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

Downstream raw materials:

6-(1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[b]thiophen-5-yl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

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