4-((R)-3-cyclohexyl-2-oxo-5-phenyl-imidazolidin-1-yl)-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-((R)-3-cyclohexyl-2-oxo-5-phenyl-imidazolidin-1-yl)-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester
CAS No.:1032818-37-3
Molecular Formula:C₃₀H₄₆N₄O₃
Molecular Weight:510.72
Hs Code.:

Synonyms:4-((R)-3-cyclohexyl-2-oxo-5-phenyl-imidazolidin-1-yl)-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester

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Chemical Property of 4-((R)-3-cyclohexyl-2-oxo-5-phenyl-imidazolidin-1-yl)-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester

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Technology Process of 4-((R)-3-cyclohexyl-2-oxo-5-phenyl-imidazolidin-1-yl)-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester

There total 10 articles about 4-((R)-3-cyclohexyl-2-oxo-5-phenyl-imidazolidin-1-yl)-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 926291-23-8
(R)-1-cyclohexyl-4-phenyl-3-(piperidin-4-yl)imidazolidin-2-one

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1032818-37-3
4-((R)-3-cyclohexyl-2-oxo-5-phenyl-imidazolidin-1-yl)-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; at 60 ℃; for 16h;

Reference yield:

: 926291-23-8
(R)-1-cyclohexyl-4-phenyl-3-(piperidin-4-yl)imidazolidin-2-one

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1032818-37-3
4-((R)-3-cyclohexyl-2-oxo-5-phenyl-imidazolidin-1-yl)-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester

Guidance literature:: (R)-1-cyclohexyl-4-phenyl-3-(piperidin-4-yl)imidazolidin-2-one; N-tert-butyloxycarbonylpiperidin-4-one; With titanium(IV)isopropoxide; In dichloromethane; at 20 ℃; for 48h; Inert atmosphere;

With diethylaluminium cyanide; In tetrahydrofuran; at 0 ℃; for 20h; Inert atmosphere;
DOI:10.1021/jm401101p

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1032818-37-3
4-((R)-3-cyclohexyl-2-oxo-5-phenyl-imidazolidin-1-yl)-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 20 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

4.1: titanium(IV)isopropoxide / dichloromethane / 48 h / 20 °C / Inert atmosphere

4.2: 20 h / 0 °C / Inert atmosphere

With pyridine; titanium(IV)isopropoxide; sodium tris(acetoxy)borohydride; acetic acid; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm401101p