N-(1-(3-cyanopyridin-2-yl)piperidin-4-yl)-N-(4-formylbenzyl)-3-morpholinopropane-1-sulfonamide

Base Information

Chemical Name:N-(1-(3-cyanopyridin-2-yl)piperidin-4-yl)-N-(4-formylbenzyl)-3-morpholinopropane-1-sulfonamide
CAS No.:1404097-70-6
Molecular Formula:C₂₆H₃₃N₅O₄S
Molecular Weight:511.645
Hs Code.:

Synonyms:N-(1-(3-cyanopyridin-2-yl)piperidin-4-yl)-N-(4-formylbenzyl)-3-morpholinopropane-1-sulfonamide

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Chemical Property of N-(1-(3-cyanopyridin-2-yl)piperidin-4-yl)-N-(4-formylbenzyl)-3-morpholinopropane-1-sulfonamide

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Technology Process of N-(1-(3-cyanopyridin-2-yl)piperidin-4-yl)-N-(4-formylbenzyl)-3-morpholinopropane-1-sulfonamide

There total 6 articles about N-(1-(3-cyanopyridin-2-yl)piperidin-4-yl)-N-(4-formylbenzyl)-3-morpholinopropane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.9%

: 1404097-65-9
2-(4-((4-formylbenzyl)amino)piperidin-1-yl)nicotinonitrile

: 3-morpholin-4-ylpropane-1-sulphonyl chloride

: 1404097-70-6
N-(1-(3-cyanopyridin-2-yl)piperidin-4-yl)-N-(4-formylbenzyl)-3-morpholinopropane-1-sulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 - 25 ℃;
DOI:10.1021/jm301164y

Reference yield:

: 6602-54-6
2-chloro-3-pyridinecarbonitrile

: 1404097-70-6
N-(1-(3-cyanopyridin-2-yl)piperidin-4-yl)-N-(4-formylbenzyl)-3-morpholinopropane-1-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

2: dichloromethane / 3 h / 0 - 25 °C

3: potassium carbonate / ethanol; water / 25 - 80 °C

4: sodium tetrahydroborate / methanol / 0.5 h / 0 - 60 °C

5: hydrogenchloride / water; acetone / 0.5 h

6: triethylamine / dichloromethane / 20 - 25 °C

With hydrogenchloride; sodium tetrahydroborate; potassium carbonate; triethylamine; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm301164y

Reference yield:

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1404097-70-6
N-(1-(3-cyanopyridin-2-yl)piperidin-4-yl)-N-(4-formylbenzyl)-3-morpholinopropane-1-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

2: dichloromethane / 3 h / 0 - 25 °C

3: potassium carbonate / ethanol; water / 25 - 80 °C

4: sodium tetrahydroborate / methanol / 0.5 h / 0 - 60 °C

5: hydrogenchloride / water; acetone / 0.5 h

6: triethylamine / dichloromethane / 20 - 25 °C

With hydrogenchloride; sodium tetrahydroborate; potassium carbonate; triethylamine; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm301164y