1-BENZYL-PYRROLIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE

Base Information

• Chemical Name: 1-BENZYL-PYRROLIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE
• CAS No.: 92086-93-6
• Molecular Formula: C12H15 N O2 . Cl H
• Molecular Weight: 241.718
• Mol file: 92086-93-6.mol

Synonyms:L-Proline,1-(phenylmethyl)-, hydrochloride (9CI)

Chemical Property of 1-BENZYL-PYRROLIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE

Chemical Property:

• Melting Point: 201-203°C
• PSA: 40.54000
• LogP: 2.47550
• Storage Temp.: Refrigerator

Purity/Quality:

97% ^*data from raw suppliers

N-Benzyl-(S)-prolineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BENZYL-PYRROLIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE

There total 3 articles about 1-BENZYL-PYRROLIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzyl chloride (100-44-7) + L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → (S)-1-benzylpyrrolidine-2-carboxylic acid hydrochloride (92086-93-6)

Guidance literature:

L-proline; With potassium hydroxide; In isopropyl alcohol; at 40 ℃;

benzyl chloride; In dichloromethane; isopropyl alcohol; at 0 - 40 ℃; for 6h;

With hydrogenchloride; In water; isopropyl alcohol; at 20 ℃; pH=4;

DOI:10.1021/jo102038q

Reference yield: 81.0%

benzyl bromide (100-39-0) + L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → (S)-1-benzylpyrrolidine-2-carboxylic acid hydrochloride (92086-93-6)

Guidance literature:

L-proline; With potassium hydroxide; In isopropyl alcohol; at 40 ℃; Inert atmosphere;

benzyl bromide; In isopropyl alcohol; at 0 - 40 ℃; for 6h; Inert atmosphere;

With hydrogenchloride; In water; isopropyl alcohol; at 20 ℃; pH=4; Inert atmosphere;

DOI:10.1002/ejoc.201301718

Reference yield:

N-benzyl-L-proline (31795-93-4) → (S)-1-benzylpyrrolidine-2-carboxylic acid hydrochloride (92086-93-6)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja00300a030

upstream raw materials:

N-benzyl-L-proline

benzyl chloride

L-proline

benzyl bromide

Downstream raw materials:

(S)-o-<(N-benzylprolyl)amino>acetophenone

(S)-2-{(N-benzyl-2-pyrrolidinyl)carbonylamino}benzaldehyde

(S)-N-(2-benzoylphenyl)-1-benzylpyrrolidine-2-carboxamide