(E)-5-(4-hydroxystyryl)-2-nitrobenzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

Base Information

Chemical Name:(E)-5-(4-hydroxystyryl)-2-nitrobenzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate
CAS No.:1384982-41-5
Molecular Formula:C₂₉H₃₀Cl₂N₂O₅
Molecular Weight:557.474
Hs Code.:

Synonyms:(E)-5-(4-hydroxystyryl)-2-nitrobenzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-5-(4-hydroxystyryl)-2-nitrobenzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

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Technology Process of (E)-5-(4-hydroxystyryl)-2-nitrobenzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

There total 14 articles about (E)-5-(4-hydroxystyryl)-2-nitrobenzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.6%

: 1384982-50-6
(E)-2-nitro-5-(4-((tetrahydro-2H-pyran-2-yl)oxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

: 1384982-41-5
(E)-5-(4-hydroxystyryl)-2-nitrobenzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 24h; Darkness;
DOI:10.1039/c2ob25701g

Reference yield:

: 1261777-72-3
2-(bromomethyl)-4-iodo-1-nitrobenzene

: 1384982-41-5
(E)-5-(4-hydroxystyryl)-2-nitrobenzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1: water; sodium carbonate / acetone / 48 h / Reflux

2: palladium diacetate / triethanolamine; N,N-dimethyl-formamide / 12 h / 110 °C / Inert atmosphere

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C / Darkness

4: trifluoroacetic acid / dichloromethane / 24 h / 20 °C / Darkness

With dmap; water; palladium diacetate; sodium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In triethanolamine; dichloromethane; N,N-dimethyl-formamide; acetone; 2: Heck reaction;
DOI:10.1039/c2ob25701g

Reference yield:

: 1384982-40-4
(E)-5-(4-ethoxystyryl)-2-nitrobenzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

: 1384982-41-5
(E)-5-(4-hydroxystyryl)-2-nitrobenzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / Irradiation

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C / Darkness

3: trifluoroacetic acid / dichloromethane / 24 h / 20 °C / Darkness

With dmap; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1039/c2ob25701g