2-((1S)-1-(5-chloro-3-(2-(methylsulfonyl)phenyl)quinoxalin-2-yl)ethyl)-isoindoline-1,3-dione

Base Information

Chemical Name:2-((1S)-1-(5-chloro-3-(2-(methylsulfonyl)phenyl)quinoxalin-2-yl)ethyl)-isoindoline-1,3-dione
CAS No.:1464832-62-9
Molecular Formula:C₂₅H₁₈ClN₃O₄S
Molecular Weight:491.955
Hs Code.:

Synonyms:2-((1S)-1-(5-chloro-3-(2-(methylsulfonyl)phenyl)quinoxalin-2-yl)ethyl)-isoindoline-1,3-dione

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Chemical Property of 2-((1S)-1-(5-chloro-3-(2-(methylsulfonyl)phenyl)quinoxalin-2-yl)ethyl)-isoindoline-1,3-dione

Chemical Property:

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Technology Process of 2-((1S)-1-(5-chloro-3-(2-(methylsulfonyl)phenyl)quinoxalin-2-yl)ethyl)-isoindoline-1,3-dione

There total 9 articles about 2-((1S)-1-(5-chloro-3-(2-(methylsulfonyl)phenyl)quinoxalin-2-yl)ethyl)-isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1464832-61-8
2-((1S)-1-(5-chloro-3-(2-(methylthio)phenyl)quinoxalin-2-yl)ethyl)isoindoline-1,3-dione

: 1464832-62-9
2-((1S)-1-(5-chloro-3-(2-(methylsulfonyl)phenyl)quinoxalin-2-yl)ethyl)-isoindoline-1,3-dione

Guidance literature:: With Oxone; In dichloromethane; water; at 15 - 21 ℃; for 96h;

Reference yield:

: 1464832-59-4
(S)-2-(1-(3,5-dichloroquinoxalin-2-yl)ethyl)isoindoline-1,3-dione

: 1464832-62-9
2-((1S)-1-(5-chloro-3-(2-(methylsulfonyl)phenyl)quinoxalin-2-yl)ethyl)-isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

2: Oxone / water; dichloromethane / 96 h / 15 - 21 °C

With Oxone; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1464832-54-9
8-chloro-3-ethylquinoxalin-2(1H)-one

: 1464832-62-9
2-((1S)-1-(5-chloro-3-(2-(methylsulfonyl)phenyl)quinoxalin-2-yl)ethyl)-isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 6 steps

1: trichlorophosphate / 2 h / 100 °C / Large scale

2: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; dibenzoyl peroxide / tetrachloromethane / 2 h / Reflux; Large scale

3: N,N-dimethyl-formamide / 3 h

4: CHIRALPAK? AS 20 μM, 11 cm id×25 cm L / hexane; isopropyl alcohol / 25 °C / Resolution of racemate

5: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

6: Oxone / water; dichloromethane / 96 h / 15 - 21 °C

With Oxone; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; potassium carbonate; trichlorophosphate; dibenzoyl peroxide; In tetrachloromethane; hexane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;