(E)-2-(cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyimino)propionic acid methyl ester

Base Information

Chemical Name:(E)-2-(cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyimino)propionic acid methyl ester
CAS No.:177275-69-3
Molecular Formula:C₂₇H₃₀N₂O₄
Molecular Weight:446.546
Hs Code.:

Synonyms:(E)-2-(cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyimino)propionic acid methyl ester

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Chemical Property of (E)-2-(cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyimino)propionic acid methyl ester

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Technology Process of (E)-2-(cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyimino)propionic acid methyl ester

There total 12 articles about (E)-2-(cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyimino)propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 600-22-6
pyruvic acid methyl ester

: 177275-01-3
O-(cyclohexyl-4-(2-quinolinylmethoxy)phenyl)methyl hydroxylamine

: 177275-68-2
(Z)-2-(cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyimino)propionic acid methyl ester

: 177275-69-3
(E)-2-(cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyimino)propionic acid methyl ester

Guidance literature:: With acetic acid; In 1,4-dioxane; methanol; water; for 24h; Ambient temperature;
DOI:10.1016/0957-4166(96)00340-0

Reference yield:

: (E/Z)-2-(cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyimino)propionic acid

: 74-88-4
methyl iodide

: 177275-68-2
(Z)-2-(cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyimino)propionic acid methyl ester

: 177275-69-3
(E)-2-(cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyimino)propionic acid methyl ester

Guidance literature:: With sodium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 72h;
DOI:10.1021/jm9904102

Reference yield:

: 3747-74-8
2-(chloromethyl)quinoline monohydrochloride

: 177275-69-3
(E)-2-(cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyimino)propionic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / K₂CO₃ / dimethylformamide / 16 h / 20 °C

2: 94 percent / tetrahydrofuran / 12 h / 20 °C

3: 99 percent / Ph₃P; diethyl azodicarboxylate / tetrahydrofuran / 14 h / 20 °C

4: 86 percent / hydrazine hydrate / ethanol; CH₂Cl₂ / 0.5 h / Heating

5: AcOH / dioxane; H₂O; methanol / 8 h / 20 °C

6: Na₂CO₃ / dimethylformamide / 72 h / 20 °C

With sodium carbonate; potassium carbonate; hydrazine hydrate; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 1: Alkylation / 2: Addition / 3: Mitsunobu reaction / 4: Substitution / 5: Condensation / 6: Esterification;
DOI:10.1021/jm9904102