Technology Process of N,N'-dibenzyl-3-nitro-6-oxazol-2-yl-pyridine-2,4-diamine
There total 9 articles about N,N'-dibenzyl-3-nitro-6-oxazol-2-yl-pyridine-2,4-diamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
oxazol;
With
n-butyllithium;
In
tetrahydrofuran;
at -78 - -60 ℃;
for 0.166667h;
Cooling with acetone-dry ice;
With
zinc(II) chloride;
In
tetrahydrofuran;
at -78 - 20 ℃;
N,N'-dibenzyl-6-bromo-3-nitropyridine-2,4-diamine;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran;
at 130 ℃;
for 0.25h;
Microwave irradiation;
- Guidance literature:
-
With
bis-triphenylphosphine-palladium(II) chloride;
In
toluene;
at 130 ℃;
for 2h;
Microwave irradiation;
Inert atmosphere;
DOI:10.1016/j.tetlet.2011.08.119
- Guidance literature:
-
Multi-step reaction with 6 steps
1: iron; acetic acid / 0.75 h
2: sulfuric acid; nitric acid / 0.5 h / -10 - -5 °C
3: sulfuric acid / 1.58 h / 47 - 56 °C
4: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C
5: potassium carbonate / tetrahydrofuran / 0 - 50 °C
6: bis-triphenylphosphine-palladium(II) chloride / toluene / 2 h / 130 °C / Microwave irradiation; Inert atmosphere
With
hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; sulfuric acid; nitric acid; iron; potassium carbonate; acetic acid; sodium nitrite;
In
tetrahydrofuran; water; toluene;
6: Stille coupling;
DOI:10.1016/j.tetlet.2011.08.119
