2-(5-dibenzylsulfamoylpyridin-3-ylamino)-2-methylpropionic acid methyl ester

Base Information

Chemical Name:2-(5-dibenzylsulfamoylpyridin-3-ylamino)-2-methylpropionic acid methyl ester
CAS No.:1043446-45-2
Molecular Formula:C₂₄H₂₇N₃O₄S
Molecular Weight:453.562
Hs Code.:

Synonyms:2-(5-dibenzylsulfamoylpyridin-3-ylamino)-2-methylpropionic acid methyl ester

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Chemical Property of 2-(5-dibenzylsulfamoylpyridin-3-ylamino)-2-methylpropionic acid methyl ester

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Technology Process of 2-(5-dibenzylsulfamoylpyridin-3-ylamino)-2-methylpropionic acid methyl ester

There total 6 articles about 2-(5-dibenzylsulfamoylpyridin-3-ylamino)-2-methylpropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 625-92-3
3,5-dibromopyridine

: 1043446-45-2
2-(5-dibenzylsulfamoylpyridin-3-ylamino)-2-methylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 1.5 h / 20 °C

1.2: 0.17 h / 0 °C

2.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / 1,3-dimethyl-2-imidazolidinone / 0.5 h / 100 °C / Microwave irradiation

4.1: trifluoroacetic acid / 0.17 h / 100 °C / Microwave irradiation

4.2: 20 °C

5.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 13 h / 90 °C

5.2: 0 - 70 °C

5.3: 20 °C / pH 5

6.1: methanol; hexane; toluene / 0.5 h / 20 °C

With isopropylmagnesium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; 1,3-dimethyl-2-imidazolidinone; methanol; hexane; dichloromethane; toluene;
DOI:10.1016/j.bmc.2010.10.023

Reference yield:

: 1043446-41-8
5-bromopyridine-3-sulfonic acid dibenzylamide

: 1043446-45-2
2-(5-dibenzylsulfamoylpyridin-3-ylamino)-2-methylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / 1,3-dimethyl-2-imidazolidinone / 0.5 h / 100 °C / Microwave irradiation

2.1: trifluoroacetic acid / 0.17 h / 100 °C / Microwave irradiation

2.2: 20 °C

3.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 13 h / 90 °C

3.2: 0 - 70 °C

3.3: 20 °C / pH 5

4.1: methanol; hexane; toluene / 0.5 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; 1,3-dimethyl-2-imidazolidinone; methanol; hexane; toluene;
DOI:10.1016/j.bmc.2010.10.023

Reference yield:

: 1043446-44-1
5-aminopyridine-3-sulfonic acid dibenzylamide

: 1043446-45-2
2-(5-dibenzylsulfamoylpyridin-3-ylamino)-2-methylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 13 h / 90 °C

1.2: 0 - 70 °C

1.3: 20 °C / pH 5

2.1: methanol; hexane; toluene / 0.5 h / 20 °C

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; hexane; toluene;
DOI:10.1016/j.bmc.2010.10.023