5-[3-(3-chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]pyridine-3-sulfonic acid dibenzylamide

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Chemical Name:5-[3-(3-chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]pyridine-3-sulfonic acid dibenzylamide
CAS No.:1259327-73-5
Molecular Formula:C₃₁H₂₆ClN₅O₃S₂
Molecular Weight:616.164
Hs Code.:

Synonyms:5-[3-(3-chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]pyridine-3-sulfonic acid dibenzylamide

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Chemical Property of 5-[3-(3-chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]pyridine-3-sulfonic acid dibenzylamide

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Technology Process of 5-[3-(3-chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]pyridine-3-sulfonic acid dibenzylamide

There total 8 articles about 5-[3-(3-chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]pyridine-3-sulfonic acid dibenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 21724-83-4
3-chloro-4-cyanobenzene isothiocyanate

: 1043446-45-2
2-(5-dibenzylsulfamoylpyridin-3-ylamino)-2-methylpropionic acid methyl ester

: 1259327-73-5
5-[3-(3-chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]pyridine-3-sulfonic acid dibenzylamide

Guidance literature:: With dmap; In toluene; at 100 ℃; for 16h;
DOI:10.1016/j.bmc.2010.10.023

Reference yield:

: 625-92-3
3,5-dibromopyridine

: 1259327-73-5
5-[3-(3-chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]pyridine-3-sulfonic acid dibenzylamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 1.5 h / 20 °C

1.2: 0.17 h / 0 °C

2.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / 1,3-dimethyl-2-imidazolidinone / 0.5 h / 100 °C / Microwave irradiation

4.1: trifluoroacetic acid / 0.17 h / 100 °C / Microwave irradiation

4.2: 20 °C

5.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 13 h / 90 °C

5.2: 0 - 70 °C

5.3: 20 °C / pH 5

6.1: methanol; hexane; toluene / 0.5 h / 20 °C

7.1: dmap / toluene / 16 h / 100 °C

With dmap; isopropylmagnesium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; 1,3-dimethyl-2-imidazolidinone; methanol; hexane; dichloromethane; toluene;
DOI:10.1016/j.bmc.2010.10.023

Reference yield:

: 1043446-41-8
5-bromopyridine-3-sulfonic acid dibenzylamide

: 1259327-73-5
5-[3-(3-chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]pyridine-3-sulfonic acid dibenzylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / 1,3-dimethyl-2-imidazolidinone / 0.5 h / 100 °C / Microwave irradiation

2.1: trifluoroacetic acid / 0.17 h / 100 °C / Microwave irradiation

2.2: 20 °C

3.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 13 h / 90 °C

3.2: 0 - 70 °C

3.3: 20 °C / pH 5

4.1: methanol; hexane; toluene / 0.5 h / 20 °C

5.1: dmap / toluene / 16 h / 100 °C

With dmap; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; 1,3-dimethyl-2-imidazolidinone; methanol; hexane; toluene;
DOI:10.1016/j.bmc.2010.10.023